| David Shulkin | 9th United States Secretary o… | 1959 |
| George Shultz | American economist, statesman… | 1920 |
| Pushyamitra Shunga | King of Sunga Dynasty | |
| Ome Shushiki | Japanese waka poet in the mid… | 1669–1725 |
| Shu-Sin | Sumerian king | |
| David Shuster | American television journalist | 1967 |
| Neal Shusterman | American novelist | 1962 |
| Nevil Shute | British racing driver | 1899–1960 |
| Steve Shutt | ice hockey player | 1952 |
| Mark Shuttleworth | South African entrepreneur; s… | 1973 |
| Richard Shweder | American anthropologist | 1945 |
| Kapil Sibal | Indian lawyer and politician | 1948 |
| Richard Sibbes | English theologian | 1577–1635 |
| Jean Sibelius | Finnish composer of the late … | 1865–1957 |
| Diodorus Siculus | Greek historiographer | -90–-30 BC |
| Parth Siddhpura | Indian singer and author | 2005 |
| Muhammad Alauddin Siddiqui | Islamic Sufi Scholar | 1936–2017 |
| Anne Rivers Siddons | novelist from the United Stat… | 1936–2019 |
| Ron Sider | Canadian theologian | 1939–2022 |
| Henry Sidgwick | English philosopher | 1838–1900 |
| Navjot Singh Sidhu | Indian cricketer and politici… | 1963 |
| Samuel Oton Sidin | 21st-century Indonesian Catho… | 1954 |
| Boris Sidis | American psychiatrist | 1867–1923 |
| Algernon Sidney | British politician and politi… | 1623–1683 |
| Philip Sidney | English diplomat | 1554–1586 |
| Bernie S. Siegel | American writer | 1932 |
| Carl Ludwig Siegel | German mathematician | 1896–1981 |
| Daniel J. Siegel | American psychiatrist | 1957 |
| Eli Siegel | Latvian-American poet, philos… | 1902–1978 |
| Jerry Siegel | American co-creator of Superm… | 1914–1996 |
| Lee Siegel | American academic | 1945 |
| Werner von Siemens | German inventor and industria… | 1816–1892 |
| Catherine of Siena | Italian Dominican saint | 1347–1380 |
| Henryk Sienkiewicz | Polish journalist, Nobel Priz… | 1846–1916 |
| José Luís Mumbiela Sierra | Spanish bishop | 1969 |
| Vincent Siew | Taiwanese politician | 1939 |
| Emmanuel-Joseph Sieyès | French ''abbé'' ad statesman | 1748–1836 |
| Charlie Sifford | professional golfer | 1922–2015 |
| Rocco Siffredi | Italian pornographic actor, d… | 1964 |
| Scott Sigler | American writer | 1969 |
| Jón Páll Sigmarsson | Icelandic strongman | 1960–1993 |
| Paul Signac | French painter | 1863–1935 |
| Lydia Sigourney | American poet | 1791–1865 |
| Keiichi Sigsawa | Japanese writer | 1972 |
| Norodom Sihanouk | Cambodian King | 1922–2012 |
| Martti Siirala | Finnish philosopher | 1889–1948 |
| Richard Siken | American poet | 1967 |
| Wladyslaw Sikorski | Polish military and political… | 1881–1943 |
| Haris Silajdžić | Bosniak politician | 1945 |
| William the Silent | stadtholder of Holland, Zeela… | 1533–1584 |
| Angelus Silesius | German writer | 1624–1677 |
| Joseph Silk | British-American astronomer | 1942 |
| Leslie Marmon Silko | American writer | 1948 |
| Stirling Silliphant | American screenwriter and fil… | 1918–1996 |
| Alan Sillitoe | British writer | 1928–2010 |
| Beverly Sills | opera soprano | 1929–2007 |
| Ignazio Silone | Italian author and politician | 1900–1978 |
| Daniel Silva | | |
| Desmond de Silva | Sri Lankan singer | |
| Luiz Inácio Lula da Silva | Brazilian politician, 35th pr… | 1945 |
| Marina Silva | Brazilian environmentalist an… | 1958 |
| Thiago Silva | Brazilian footballer | 1984 |
| Ulisses Correia e Silva | Cape Verdean politician | 1962 |
| Joan Micklin Silver | American film director | 1935–2020 |
| Nate Silver | American statistician and wri… | 1978 |
| Susan Silver | American music manager | 1958 |
| Adam Silvera | American author | 1990 |
| Robert Silverberg | American speculative fiction … | 1935 |
| David Silverman | American animator and director | 1957 |
| Sarah Silverman | American comedian and actress | 1970 |
| Shel Silverstein | American poet, cartoonist, an… | 1930–1999 |
| Alicia Silverstone | American actress | 1976 |
| Dave Sim | Canadian cartoonist, creator … | 1956 |
| Clifford D. Simak | American writer, journalist | 1904–1988 |
| Georges Simenon | Belgian writer | 1903–1989 |
| Charles Simic | American poet | 1938 |
| Michael Simkins | British actor | 1956 |
| Georg Simmel | German sociologist, philosoph… | 1858–1918 |
| Billy Simmonds | | 1980 |
| Charles Simmons | American editor and writer | 1924–2017 |
| Dan Simmons | American novelist | 1948 |
| Gene Simmons | Israeli-born American rock ba… | 1949 |
| Jamal Simmons | American journalist | 1971 |
| Jean Simmons | British-American actress | 1929–2010 |
| Lendl Simmons | West Indian cricketer | 1985 |
| Maryanne Ellison Simmons | American printmaker | 1949 |
| Rachel Simmons | American writer | 1974 |
| Russell Simmons | American entrepreneur, produc… | 1957 |
| Carly Simon | American singer-songwriter, m… | 1943 |
| Gilles Simon | French tennis player | 1984 |
| Herbert A. Simon | American political scientist,… | 1916–2001 |
| Julian Simon | American economist | 1932–1998 |
| Michele Simon | public health lawyer | 1965 |
| Neil Simon | playwright, writer, academic | 1927–2018 |
| Paul Simon | American musician, songwriter… | 1941 |
| S. J. Simon | British bridge player and wri… | 1904–1948 |
| Fernando Simón | Spanish physician | 1963 |
| Gilbert Simondon | 20th century French philosoph… | 1924–1989 |
| Gail Simone | writer | 1974 |
| Nina Simone | American singer, songwriter, … | 1933–2003 |
