| Shan Sa | Author | 1972 |
| Saadi | Persian poet | 1210–1291 |
| Aiysha Saagar | Australian singer | 1980 |
| Mikheil Saakashvili | Georgian-Ukrainian politician… | 1967 |
| Yousef Saanei | Iranian grand ayatollah | 1937 |
| Irene Sabatini | writer from Zimbabwe | 1967 |
| Rafael Sabatini | Italian writer | 1875–1950 |
| Ernesto Sábato | Argentine writer, painter and… | 1911–2011 |
| Michel Sabbah | Latin Patriarchs of Jerusalem | 1933 |
| Florence R. Sabin | American medical scientist | 1871–1953 |
| Fernando Sabino | Brazilian writer | 1923–2004 |
| Mohamad Sabu | Defence Minister of Malaysia | 1954 |
| Sabuktigin | Founder of the Ghaznavid Empi… | 942–997 |
| Arrigo Sacchi | Italian footballer | 1946 |
| Joe Sacco | Maltese-American cartoonist a… | 1960 |
| Louis Sachar | American writer of children's… | 1954 |
| Leopold von Sacher-Masoch | Austrian author | 1836–1895 |
| Andrew Sachs | British actor | 1930–2016 |
| Jeffrey D. Sachs | American economist | 1954 |
| Jonathan Sacks | British rabbi | 1948 |
| Oliver Sacks | British neurologist and writer | 1933–2015 |
| Vita Sackville-West | English writer and gardener | 1892–1962 |
| Anwar Sadat | Egyptian president and Nobel … | 1918–1981 |
| Marquis de Sade | French novelist and philosoph… | 1740–1814 |
| Sadhguru | Yogi, mystic, visionary and h… | 1957 |
| Jason Scott Sadofsky | American technology historian… | 1970 |
| Jerry Sadowitz | Scottish comedian | 1961 |
| Muqtada Sadr | Iraqi politician | 1973 |
| Moshe Safdie | Israeli-Canadian architect | 1938 |
| Paul Saffo | American writer | 1954 |
| Carl Safina | American biologist | 1955 |
| Howard Safir | | 1941 |
| William Safire | American journalist | 1929–2009 |
| Carl Sagan | American astrophysicist, cosm… | 1934–1996 |
| Françoise Sagan | French writer | 1935–2004 |
| Kamal Sagar | Architect | 1969 |
| Angie Sage | English author and illustrator | 1952 |
| Bob Saget | American stand-up comedian, a… | 1956 |
| Kenji Sahara | Japanese actor | 1932 |
| Mort Sahl | American comedian and actor | 1927–2021 |
| Mona Sahlin | Swedish politician | 1957 |
| Edward Said | Professor of English and lite… | 1935–2003 |
| Kais Saied | Tunisian politician, academic… | 1958 |
| K. L. Saigal | Indian actor | 1904–1947 |
| Ihara Saikaku | Japanese writer | 1642–1693 |
| Robin Saikia | British writer and actor | |
| Nattawut Saikua | Thai politician | 1975 |
| Steve Sailer | American journalist and movie… | 1958 |
| Lilith Saintcrow | American writer | 1976 |
| Charles Augustin Sainte-Beuve | French literary critic | 1804–1869 |
| Buffy Sainte-Marie | Canadian musician | 1941 |
| Antoine de Saint-Exupéry | French writer and aviator | 1900–1944 |
| Mellin de Saint-Gelais | French poet | 1495–1558 |
| Louis Antoine de Saint-Just | military and political leader | 1767–1794 |
| Jacques-Henri Bernardin de Saint-Pierre | writer and botanist from Fran… | 1737–1814 |
| John Taylor (Latter Day Saints) | third president of The Church… | 1808–1887 |
| Camille Saint-Saëns | French composer, organist, co… | 1835–1921 |
| George Saintsbury | British literary critic | 1845–1933 |
| Henri de Saint-Simon | French early socialist theori… | 1760–1825 |
| George Saitoti | Kenyan politician | 1945–2012 |
| Pat Sajak | American television host | 1946 |
| Guy Sajer | French military writer and ca… | 1927 |
| Nanao Sakaki | Japanese poet | 1923–2008 |
| Eisuke Sakakibara | Japanese economist and critic | 1941 |
| Marcus Sakey | American musician | 1974 |
| Andrei Sakharov | Soviet nuclear physicist and … | 1921–1989 |
| Saki | British writer | 1870–1916 |
| Itsurō Sakisaka | Japanese economist | 1897–1985 |
| Riiko Sakkinen | Finnish visual artist | 1976 |
| J. J. Sakurai | American physicist | 1933–1982 |
| George Augustus Henry Sala | British journalist | 1828–1895 |
| Xavier Sala-i-Martin | Catalan economist | 1962 |
| Abdus Salam | theoretical physicist, and No… | 1926–1996 |
| Hannu Salama | Finnish writer | 1936 |
| Nina Salaman | British Jewish poet, translat… | 1877–1925 |
| Daniel Salamanca | President of Bolivia (1863-19… | 1863–1935 |
| Hossein Salami | Iranian military officer; com… | 1960 |
| Epiphanius of Salamis | Christian bishop and saint | 315–403 |
| Gerald R. Salancik | American organizational theor… | 1943–1996 |
| Joel Salatin | American environmentalist | 1957 |
| Alberto Salazar | American track coach and long… | 1958 |
| António de Oliveira Salazar | Prime Minister of Portugal | 1889–1970 |
| Zainab Salbi | Iraqi American author, women'… | 1969 |
| V.J.P. Saldanha | | |
| Ali Abdullah Saleh | President of North Yemen from… | 1947–2017 |
| Alfano I, Archbishop of Salerno | Archbishop of Salerno | 1015–1085 |
| Francis de Sales | French bishop, saint, writer … | 1567–1622 |
| William Saletan | American journalist | 1964 |
| Bill Sali | American politician | 1954 |
| Antonio Salieri | Italian classical composer an… | 1750–1825 |
| Emily Saliers | singer-songwriter, restaurate… | 1963 |
| Barham Salih | President of Iraq | 1960 |
| Carol Saline | American journalist | |
| Jerome David Salinger | American writer | 1919–2010 |
| John of Salisbury | English philosopher and theol… | |
| Robert Cecil, 1st Earl of Salisbury | English Earl | 1563–1612 |
| Robert Gascoyne-Cecil, 3rd Marquess of Salisbury | British politician | 1830–1903 |
| Johann Gaudenz von Salis-Seewis | Swiss poet, author, politicia… | 1762–1834 |
| Jonas Salk | Inventor of polio vaccine | 1914–1995 |
| Macky Sall | current President and former … | 1961 |
