| Didier Sornette | French scientist | 1957 |
| Pitirim Sorokin | American sociologist | 1889–1968 |
| George Soros | Hungarian-American business m… | 1930 |
| Gilbert Sorrentino | American writer | 1929–2006 |
| Stanisław Sosabowski | Polish general | 1892–1967 |
| Musō Soseki | Japanese Zen-Buddhist teacher… | 1275–1351 |
| Natsume Soseki | Japanese novelist | 1867–1916 |
| Heidi Sosik | researcher | |
| Antonio Dorado Soto | Spanish bishop | 1931–2015 |
| Gary Soto | American poet and writer | 1952 |
| Jesús Huerta de Soto | professor of political econom… | 1956 |
| Sonia Sotomayor | U.S. Supreme Court Justice | 1954 |
| Bernadette Soubirous | French saint | 1844–1879 |
| Anna Soubry | British politician | 1956 |
| Robert D. San Souci | Children's writer | 1946–2014 |
| Ahdaf Soueif | Egyptian novelist | 1950 |
| Pierre Soulages | French painter and engraver | 1919 |
| Jeremy Soule | American composer | 1975 |
| Sister Souljah | American hip hop-generation a… | 1964 |
| Berhaneyesus Demerew Souraphiel | Ethiopian Catholic Archbishop… | 1948 |
| João Sousa | Portuguese tennis player | 1989 |
| William Soutar | British poet | 1898–1943 |
| Brian Souter | British businessman | 1954 |
| David Souter | Judge of the United States of… | 1939 |
| Robert South | English theologian | 1634–1716 |
| Lauren Southern | Canadian libertarian commenta… | 1995 |
| Terry Southern | American author | 1924–1995 |
| Thomas Southerne | Irish dramatist | 1660–1746 |
| Robert Southey | British poet | 1774–1843 |
| Robert Southwell | English Jesuit | 1561–1595 |
| Chaim Soutine | painter | 1893–1943 |
| Bruno de Souza | | |
| John F. Sowa | artificial intelligence resea… | 1940 |
| Jack B. Sowards | American screenwriter | 1929–2007 |
| Thomas Sowell | American economist, social th… | 1930 |
| Raphael Soyer | American artist | 1899–1987 |
| Wole Soyinka | Nigerian writer | 1934 |
| Harry E. Soyster | Recipient of the Purple Heart… | 1935 |
| Paul-Henri Spaak | Belgian politician | 1899–1972 |
| Kevin Spacey | American actor, director and … | 1959 |
| David Spade | American stand-up comedian | 1964 |
| Dean Spade | American activist | 1977 |
| Kate Spade | American fashion designer | 1962–2018 |
| James Spader | American actor | 1960 |
| Gene Spafford | American computer scientist | 1956 |
| Jens Spahn | German politician | 1980 |
| Philip II of Spain | King of Spain who became King… | 1527–1598 |
| Esperanza Spalding | American jazz bassist and sin… | 1984 |
| John Lancaster Spalding | Catholic bishop | 1840–1916 |
| Walter Raymond Spalding | American music pedagogue and … | 1865–1962 |
| Tom Spanbauer | American writer | 1946 |
| Bianca Sparacino | | |
| Max Sparber | | 1968 |
| Muriel Spark | Scottish writer | 1918–2006 |
| Beatrice Sparks | American writer | 1917–2012 |
| Jordin Sparks | American singer, winner of 20… | 1989 |
| Kerrelyn Sparks | American writer | 1955 |
| Nicholas Sparks | American writer and novelist | 1965 |
| Theresa Sparks | American activist | 1949 |
| Jeff Sparrow | Australian writer | 1969 |
| Mighty Sparrow | Grenadian musician | 1935 |
| Elbridge G. Spaulding | American politician | 1809–1897 |
| Elizabeth George Speare | American writer | 1908–1994 |
| Britney Spears | American singer, dancer and a… | 1981 |
| Arlen Specter | American politician; former U… | 1930–2012 |
| Phil Spector | American record producer, son… | 1939–2021 |
| Barbara Lerner Spectre | Israeli academic | 1942 |
| Albert Speer | German architect, Minister of… | 1905–1981 |
| Jackie Speier | American politician | 1950 |
| Regina Spektor | American singer-songwriter an… | 1980 |
| E. Lee Spence | German anthropologist, photog… | 1947 |
| Gerry Spence | American lawyer | 1929 |
| Colin Spencer | British writer | 1933 |
| Herbert Spencer | English philosopher, biologis… | 1820–1903 |
| Ichabod Spencer | American minister | 1798–1854 |
| LaVyrle Spencer | American writer | 1943 |
| Richard Bertrand Spencer | American white supremacist | 1978 |
| Robert Spencer | American author and blogger | 1962 |
| Roy Spencer | American meteorologist | 1955 |
| Stanley Spencer | English painter | 1891–1959 |
| William Robert Spencer | British poet | 1770–1834 |
| G. Spencer-Brown | British mathematician | 1923–2016 |
| Stephen Spender | English poet and man of lette… | 1909–1995 |
| Oswald Spengler | German historian and philosop… | 1880–1936 |
| Edmund Spenser | English poet | 1552–1599 |
| Victor Sperandeo | American businessman | 1945 |
| Roberto Speranza | Italian politician | 1979 |
| Roger Wolcott Sperry | American neuroscientist | 1913–1994 |
| Gus Speth | | |
| James Gustave Speth | American environmental lawyer… | 1942 |
| Adrienne von Speyr | Swiss doctor and mystic | 1902–1967 |
| Sean Spicer | American political strategist… | 1971 |
| Art Spiegelman | cartoonist from the United St… | 1948 |
| Erik Spiekermann | German typographer | 1947 |
| Steven Spielberg | American film director, scree… | 1946 |
| August Spies | American upholsterer, radical… | 1855–1887 |
| Mickey Spillane | American writer | 1918–2006 |
| Pat Spillane | Gaelic football player | 1955 |
| Jerry Spinelli | American children's writer | 1941 |
| Baruch Spinoza | Dutch philosopher | 1632–1677 |
