| Wilfred Cantwell Smith | Canadian academic | 1916–2000 |
| Will Smith | American actor, film producer… | 1968 |
| Zadie Smith | British writer | 1975 |
| Jeri Smith-Ready | | |
| Robert Smithson | American artist | 1938–1973 |
| Smohalla | Native American prophet-dream… | 1815–1895 |
| Lee Smolin | American cosmologist | 1955 |
| Jurnee Smollett | American actress | 1986 |
| Jussie Smollett | American actor, singer, direc… | 1982 |
| Tobias Smollett | 18th-century poet and author … | 1721–1771 |
| George Smoot | American astrophysicist and c… | 1945 |
| Raymond Smullyan | American mathematician | 1919–2017 |
| Barbara Smuts | American anthropologist | 1950 |
| Jan Smuts | military leader, politician a… | 1870–1950 |
| Rob Smyth | English/Irish rugby league pl… | 1977 |
| William Henry Smyth | English naval officer and hyd… | 1788–1865 |
| John Snaith | British cricketer (1876-) | 1876–1936 |
| Bruno Snell | German classical philologist | 1896–1986 |
| Jan L. A. van de Snepscheut | Dutch computer scientist | 1953–1994 |
| Todd Snider | American singer | 1966 |
| Thomas E. Sniegoski | writer | 1962 |
| Wesley Snipes | film actor, Martial artist, f… | 1962 |
| Melinda M. Snodgrass | American writer | 1951 |
| W.D. Snodgrass | Poet | 1926–2009 |
| C. P. Snow | British writer | 1905–1980 |
| Lorenzo Snow | President of The Church of Je… | 1814–1901 |
| Tony Snow | American White House Press Se… | 1955–2008 |
| Edward Snowden | American whistleblower and fo… | 1983 |
| Leigh Snowden | American actress | 1929–1982 |
| Philip Snowden, 1st Viscount Snowden | British politician | 1864–1937 |
| Princess Margaret, Countess of Snowdon | younger daughter of King Geor… | 1930–2002 |
| Olympia Snowe | United States Senator from Ma… | 1947 |
| Gary Snyder | American poet | 1930 |
| Scott Snyder | American writer | 1976 |
| Timothy D. Snyder | American author and historian | 1969 |
| Zack Snyder | American film director, film … | 1966 |
| Zilpha Keatley Snyder | American writer of children's… | 1927–2014 |
| Yehoshua Sobol | Israeli dramatist | 1939 |
| Luísa Sobral | Portuguese singer and songwri… | 1987 |
| Salvador Sobral | Portuguese singer | 1989 |
| Jon Sobrino | Spanish theologian | 1938 |
| Socrates | classical Greek Athenian phil… | -470–-399 BC |
| Park So-dam | South Korean actress | 1991 |
| Frederick Soddy | chemist and physicist from En… | 1877–1956 |
| Don Soderquist | | 1934–2016 |
| Manasseh Sogavare | Solomon Islands politician | 1955 |
| Mugaku Sogen | | 1226–1286 |
| Antonio Simeone Sografi | Italian playwright | 1759–1818 |
| Timo Soini | Finnish politician | 1962 |
| Kimsa Sok | Cambodian tour guide | 2003 |
| Daniel Sokatch | CEO of the New Israel Fund | 1968 |
| Grigori Sokolnikov | Soviet diplomat | 1888–1939 |
| Valerie Solanas | American radical feminist and… | 1936–1988 |
| Folake Solanke | Nigerian lawyer | 1932 |
| Qasem Soleimani | Iranian senior military offic… | 1957–2020 |
| Hilda Solis | 25th United States Secretary … | 1957 |
| Octavio Solis | | 1958 |
| Philippe Sollers | French philosopher | 1936 |
| Rebecca Solnit | Author and essayist from Unit… | 1961 |
| Hope Solo | American association football… | 1981 |
| Solomon | king of Israel and the son of… | -990–-931 BC |
| Andrew Solomon | American journalist | 1963 |
| Norman Solomon | American journalist, media cr… | 1951 |
| Dionysios Solomos | Greek poet | 1798–1857 |
| Solón | Athenian legislator | -638–-558 BC |
| Larry Solov | American attorney and media e… | 1968 |
| Joseph B. Soloveitchik | American theologian | 1903–1993 |
| Simon Soloveychik | Russia writer and philosopher | 1930–1996 |
| Robert Solow | American economist | 1924 |
| Georg Solti | Hungarian orchestral and oper… | 1912–1997 |
| Ernest Solvay | Belgian chemist, industrialis… | 1838–1922 |
| Aleksandr Solzhenitsyn | Russian writer | 1918–2008 |
| Eduardo Martínez Somalo | cardinal of the Catholic Chur… | 1927–2021 |
| Nicolaus Sombart | German sociologist | 1923–2008 |
| Werner Sombart | German economist, sociologist… | 1863–1941 |
| William Somervile | English poet | 1675–1742 |
| Ilya Somin | American law school professor | 1973 |
| Arnold Sommerfeld | physicist | 1868–1951 |
| Christina Hoff Sommers | American author and philosoph… | 1950 |
| Stephen Sommers | American film director | 1962 |
| Stephen Sondheim | American composer and lyricist | 1930 |
| Sonya Sones | American writer | 1950 |
| Hannah Song | American activist | |
| Pu Songling | Chinese writer | 1640–1715 |
| Jordan Sonnenblick | American writer | 1969 |
| Pierre Sonnerat | French botanist (1748-1814) | 1748–1814 |
| Susan Sontag | American writer and filmmaker… | 1933–2004 |
| Nikki SooHoo | American actress | 1988 |
| James Soong | Chairman of People First Part… | 1942 |
| Lee Soon-ok | activist, former political pr… | 1947 |
| Nazarene Soosai | | 1963 |
| Sophocles | ancient Greek tragedian | -496–-406 BC |
| Kaikhosru Shapurji Sorabji | English composer, music criti… | 1892–1988 |
| Soraya | Singer-songwriter | 1969–2006 |
| Georges Sorel | French philosopher and sociol… | 1847–1922 |
| Charles E. Sorensen | American businessman | 1881–1968 |
| Annika Sörenstam | Swedish golfer | 1970 |
| Soleil Sorge | American naturalized Italian … | 1994 |
| Moon So-ri | South Korean actress | 1974 |
| Aaron Sorkin | American screenwriter, produc… | 1961 |
