| Jeff Sessions | Former United States Attorney… | 1946 |
| Vikram Seth | Indian writer | 1952 |
| Anya Seton | American writer | 1904–1990 |
| Ernest Thompson Seton | British/ American author, art… | 1860–1946 |
| Diane Setterfield | English novelist | 1964 |
| Mary Lee Settle | Novelist, biographer, academic | 1918–2005 |
| Settlemania | Settlemania Is in Indian Vide… | 1999 |
| Michel Seuphor | designer, draughtsman, painter | 1901–1999 |
| Georges Seurat | French painter | 1859–1891 |
| Dr. Seuss | American children's writer an… | 1904–1991 |
| Eric Sevareid | American journalist | 1912–1992 |
| Gino Severini | Italian painter | 1883–1966 |
| Septimius Severus | Emperor of Ancient Rome | 145–211 |
| Sulpicius Severus | Christian writer and historia… | 360–420 |
| Marie de Rabutin-Chantal, marquise de Sévigné | French noble | 1626–1696 |
| Chloë Sevigny | American film actress | 1974 |
| Isidore of Seville | bishop, confessor and doctor … | 560–636 |
| Harriet Winslow Sewall | American poet | 1819–1889 |
| Jonathan M. Sewall | American poet | 1748–1808 |
| William H. Seward | American lawyer and politician | 1801–1872 |
| Anna Sewell | English novelist | 1820–1878 |
| Quintus Sextius | Roman philosopher | |
| Anne Sexton | poet from the United States | 1928–1974 |
| Jared Yates Sexton | | 1981 |
| Tokyo Sexwale | South African politician | 1953 |
| Léa Seydoux | French actress | 1985 |
| Ed Seykota | American commodities trader | 1946 |
| Jane Seymour | English-American actress | 1951 |
| Jill Seymour | British politician | 1958 |
| Arthur Seyss-Inquart | austrian chancellor and polit… | 1892–1946 |
| Elio Sgreccia | Catholic cardinal | 1928–2019 |
| Jeff Shaara | American writer | 1952 |
| Michael Shaara | American writer | 1928–1988 |
| Oksana Shachko | Ukrainian artist and activist… | 1987–2018 |
| Max Shachtman | American Marxist theorist | 1904–1972 |
| G. L. S. Shackle | British economist | 1903–1992 |
| Ernest Shackleton | Anglo-Irish polar explorer | 1874–1922 |
| Tim Shadbolt | New Zealand politician | 1947 |
| John Shadegg | American politician | 1949 |
| DJ Shadow | American trip-hop musician | 1972 |
| Idegu Ojonugwa Shadrach | | 1995 |
| Thomas Shadwell | English poet and playwright | 1642–1692 |
| Tom Shadyac | American film director | 1958 |
| Elif Shafak | Turkish writer | 1971 |
| Jim G. Shaffer | American archaeologist | 1944 |
| Peter Shaffer | English playwright and screen… | 1926–2016 |
| Mian Muhammad Shafi | Member of Imperial Legislativ… | 1869–1932 |
| Anthony Ashley Cooper, 1st Earl of Shaftesbury | English politician and Earl | 1621–1683 |
| Anthony Ashley-Cooper, 3rd Earl of Shaftesbury | English politician and Earl | 1671–1713 |
| Ethan H. Shagan | American historian | 1971 |
| Alauddin Husain Shah | Sultan of Bengal | |
| Amit Shah | Indian politician | 1964 |
| Bulleh Shah | Punjabi poet | 1680–1757 |
| Idries Shah | writer and Sufi teacher | 1924–1996 |
| Nader Shah | ruled as Shah of Iran | 1688–1747 |
| Nathar Shah | Muslim missionary | 969–1039 |
| Owais Shah | | |
| Prithvi Narayan Shah | far-sighted king/unifier of N… | 1722–1775 |
| Wajid Ali Shah | Nawab of Awadh | 1822–1887 |
| Rezā Shāh | Shah of the Imperial State of… | 1878–1944 |
| Syed Shahabuddin | Indian politician | 1935–2017 |
| Jennifer Shahade | chess player | 1980 |
| Israel Shahak | Israeli academic | 1933–2001 |
| Liu Shahe | Chinese writer and poet | 1931–2019 |
| Jeanne Shaheen | American politician | 1947 |
| Riaz Ahmed Gohar Shahi | Pakistani Sufi spiritual lead… | 1941–2001 |
| Mahmoud Hashemi Shahroudi | Iranian politician and cleric | 1948–2018 |
| Anwar Shaikh | British Pakistani writer | 1928–2006 |
| Merle Shain | Canadian writer | 1935–1989 |
| John Campbell Shairp | British writer | 1819–1885 |
| Shaka | leader of the Zulu Kingdom | 1787–1828 |
| Alex Shakar | American writer | 1968 |
| William Shakespeare | English playwright and poet | 1564–1616 |
| Parveen Shakir | Pakistani writer and poet | 1952–1994 |
| Shakira | Colombian singer | 1977 |
| Assata Shakur | American activist who was a m… | 1947 |
| Tupac Shakur | rapper and actor | 1971–1996 |
| Emanuel Hana Shaleta | prelate of the Chaldean Catho… | 1956 |
| Wendy Shalit | American writer | 1975 |
| Willa Shalit | American artist | 1955 |
| Jill Shalvis | American writer | 1963 |
| Yitzhak Shamir | prime minister of Israel | 1915–2012 |
| Ahmad Shamlou | Iranian Persian poet, writer,… | 1925–2000 |
| Shammai | | |
| Kamila Shamsie | Pakistani writer | 1973 |
| Darren Shan | Irish writer of English-langu… | 1972 |
| John Hung Shan-chuan | Archbishop of the Roman Catho… | 1943 |
| Sara Shane | American actress | 1928–2022 |
| Ntozake Shange | Contemporary African American… | 1948–2018 |
| Li Shangyin | | |
| Li Shangyin | Chinese poet and writer | 813–858 |
| Ravi Shankar | Indian musician and sitar pla… | 1920–2012 |
| Sri Sri Ravi Shankar | spiritual leader | 1956 |
| Adi Shankara | Hindu philosopher monk of 8th… | 788–820 |
| Edward A. Shanken | American art historian | 1964 |
| Bill Shankly | Scottish footballer and manag… | 1913–1981 |
| Claude Elwood Shannon | American mathematician and in… | 1916–2001 |
| Molly Shannon | American actress | 1964 |
| Yuan Shao | Han Dynasty warlord | 154–202 |
| Liu Shaoqi | 2nd President of the People's… | 1898–1969 |
