| Brady Udall | American novelist, short stor… | 1971 |
| Morris Udall | American politician | 1922–1998 |
| Nicholas Udall | English playwright | 1505–1556 |
| Fumito Ueda | Japanese video game designer | 1970 |
| Brenda Ueland | Journalist and writer | 1891–1985 |
| Morihei Ueshiba | founder of aikido | 1883–1969 |
| Fritz von Uhde | German artist | 1848–1911 |
| Ludwig Uhland | German poet | 1787–1862 |
| Joseph Edra Ukpo | Nigerian priest (1937–2023) | 1937 |
| Stanislaw Ulam | Polish-American mathematician | 1909–1984 |
| Walter Ulbricht | German politician | 1893–1973 |
| Ellen Ullman | American writer | 1949 |
| Tracey Ullman | English-born actress, comedia… | 1959 |
| Ulpian | Roman jurist | 170–228 |
| Dave Ulrich | American academic | 1953 |
| Georgia Ulrich | | |
| Lars Ulrich | Danish musician | 1963 |
| Laurel Thatcher Ulrich | American historian | 1938 |
| Karl Heinrich Ulrichs | German jurist, writer and pio… | 1825–1895 |
| Björn Ulvaeus | Swedish musician | 1945 |
| Umar | Second Caliph of Rashidun Cal… | 585–644 |
| Yoshijirō Umezu | Japanese general | 1882–1949 |
| Stuart A. Umpleby | American scientist | 1944 |
| Thrity Umrigar | Indian writer/Parsi author/Pa… | 1961 |
| Ko Un | korean poet | 1933 |
| Miguel de Unamuno | 19th-20th century Spanish wri… | 1864–1936 |
| Evelyn Underhill | British saint, poet, novelist | 1875–1941 |
| Carrie Underwood | American country music singer | 1983 |
| Sigrid Undset | Norwegian writer | 1882–1949 |
| Loung Ung | American academic | 1970 |
| Giuseppe Ungaretti | poet and writer from Italy | 1888–1970 |
| Lisa Unger | American author | 1970 |
| Peter Unger | American philosopher | 1942 |
| Roberto Mangabeira Unger | Brazilian philosopher and pol… | 1947 |
| Orl Unho | | 1976 |
| Isabel II do Reino Unido | queen of the UK, Canada, Aust… | 1926–2022 |
| Barry Unsworth | English novelist | 1930–2012 |
| Louis Untermeyer | American poet | 1885–1977 |
| Deendayal Upadhyaya | RSS thinker and co-founder of… | 1916–1968 |
| John Updike | American novelist, poet, shor… | 1932–2009 |
| Thomas Cogswell Upham | American philosopher and psyc… | 1799–1872 |
| Caitlin Upton | American model | 1989 |
| Kate Upton | American model and actress | 1992 |
| Ian Urbina | American journalist | 1972 |
| Andrew Ure | Scottish doctor and chemist | 1778–1857 |
| Leon Uris | American novelist | 1924–2003 |
| Brian Urlacher | All-American college football… | 1978 |
| Luis Alberto Urrea | Mexican-American poet | 1955 |
| Anne Ursu | American writer | 1900 |
| Lyndall Urwick | British management consultant | 1891–1983 |
| William Ury | American writer; co-founder o… | 1953 |
| Usher | American singer, songwriter, … | 1978 |
| Michael E. Uslan | American film producer | 1951 |
| Johann Martin Usteri | Swiss poet | 1763–1827 |
| Dmitriy Ustinov | Soviet military commander and… | 1908–1984 |
| Peter Ustinov | English actor, writer, and dr… | 1921–2004 |
| Antje Utgaard | American actress | 1994 |
| Uthman | Companion of Muhammad and thi… | 574–656 |
| Marcus Porcius Cato Uticensis | politician and writer (BCE 95… | -95–-46 BC |
| Jahonotin Uvaysiy | Uzbekistani poet | 1781–1845 |
| Cenk Uygur | Turkish-American online news … | 1970 |
| Douglas Den Uyl | American philosopher | 1950 |
| Jamie Uys | South African film director | 1921–1996 |
| Pieter-Dirk Uys | South African comedian | 1945 |
