| Sandra Seaton | Playwright and writer | |
| Chief Seattle | Duwamish chief | 1786–1866 |
| Sergio Sebastiani | Catholic cardinal | 1931 |
| Mosadi Seboko | kgosikgolo of the Balete peop… | 1950 |
| Alice Sebold | American writer | 1963 |
| Pedro Muñoz Seca | Spanish writer | 1879–1936 |
| Harry Secombe | British entertainer | 1921–2001 |
| Michel-Jean Sedaine | French writer | 1719–1797 |
| Amy Sedaris | American comedian | 1961 |
| David Sedaris | American author | 1956 |
| Edie Sedgwick | Socialite, actress, model | 1943–1971 |
| Eve Kosofsky Sedgwick | American academic | 1950–2009 |
| John Sedgwick | Union Army general | 1813–1864 |
| Marcus Sedgwick | British writer and illustrator | 1968 |
| Charles Sedley | English politician | 1639–1701 |
| Jules Sedney | Prime Minister of Suriname (1… | 1922–2020 |
| Lee Sedol | South Korean Go player | 1983 |
| Carolyn See | American writer | 1934–2016 |
| Lisa See | American writer and novelist | 1955 |
| Dieter Seebach | German chemist | 1937 |
| Hans von Seeckt | German general | 1866–1936 |
| Richard Seed | American physicist and entrep… | 1928 |
| Charles Seeger | American musicologist | 1886–1979 |
| Pete Seeger | American folk singer | 1919–2014 |
| John Robert Seeley | British historian | 1834–1895 |
| Julius Hawley Seelye | American politician | 1824–1895 |
| Giorgos Seferis | Greek poet and diplomat | 1900–1971 |
| Andrew Sega | musician from America | 1975 |
| Erich Segal | American writer | 1937–2010 |
| Bob Seger | American singer-songwriter | 1945 |
| Liliana Segre | Italian Holocaust survivor an… | 1930 |
| Enrique Eguía Seguí | Catholic bishop | 1962 |
| Nathan Seiberg | American physicist | 1956 |
| Tim Seibles | American poet | 1955 |
| Jaroslav Seifert | Czechoslovak poet, Nobel priz… | 1901–1986 |
| John Seigenthaler | American journalist, writer, … | 1927–2014 |
| Jerry Seinfeld | American comedian and actor | 1954 |
| Frederick Seitz | American physicist | 1911–2008 |
| Samuel Sejjaaka | Ugandan businessman | 1964 |
| Mobutu Sésé Seko | President of Zaïre | 1930–1997 |
| Haile Selassie | Emperor of Ethiopia | 1892–1975 |
| John Selden | English jurist and scholar of… | 1584–1654 |
| George Seldes | American journalist | 1890–1995 |
| Selena | Mexican-American singer, song… | 1971–1995 |
| Will Self | English writer and journalist | 1961 |
| Harry Gordon Selfridge | America born English business… | 1858–1947 |
| George Selgin | economist | 1957 |
| Bud Selig | American baseball executive | 1934 |
| Meša Selimović | Yugoslav-Bosnian writer | 1910–1982 |
| Peter Sellars | American theatre director | 1957 |
| Tom Selleck | American actor | 1945 |
| Peter Sellers | British film actor, comedian … | 1925–1980 |
| Sean Sellers | American murderer | 1969–1999 |
| Reinhard Selten | German economist | 1930–2016 |
| Sarah Seltzer | | |
| Antony Selvanayagam | Catholic bishop | 1935 |
| Brian Selznick | American children's illustrat… | 1966 |
| Philip Selznick | American sociologist | 1919–2010 |
| Ousmane Sembène | Senegalese film director, pro… | 1923–2007 |
| Vasyl Semeniuk | eparch of the Ukrainian Greek… | 1949 |
| Ricardo Semler | Brazilian businessman | 1959 |
| Jorge Semprún | Spanish writer | 1923–2011 |
| Amartya Sen | Indian economist | 1933 |
| Aparna Sen | Indian filmmaker, script writ… | 1945 |
| Keshub Chunder Sen | Indian academic | 1838–1884 |
| Melissa Senate | american writer | 1965 |
| Maurice Sendak | American illustrator and writ… | 1928–2012 |
| Irena Sendler | Polish resistance fighter and… | 1910–2008 |
| Marcus Annaeus Seneca | Roman scholar | -54–39 BC |
| Seneca the Younger | Roman Stoic philosopher, stat… | -4–65 BC |
| Hannah Senesh | Jewish poet and anti-nazi fig… | 1921–1944 |
| Ho Iat Seng | Chief Executive of Macau | 1957 |
| Simon Peter Poh Hoon Seng | Malaysian prelate | 1963 |
| Sengai | Japanese artist | 1750–1837 |
| Peter M. Senge | American scientist | 1947 |
| Jona Senilagakali | Prime Minister of Fiji | 1929–2011 |
| Ayrton Senna | Brazilian racing driver | 1960–1994 |
| Sennacherib | King of Assyria | -740–-681 BC |
| Senthil | | |
| Jung Myung Seok | South Korean Leader of New Re… | 1945 |
| Crescenzio Sepe | Italian Catholic cardinal | 1943 |
| Sohrab Sepehri | Iranian poet and painter | 1928–1980 |
| Frank Serafini | American politician | 1945 |
| Ismail Serageldin | egyptian academic | 1944 |
| Julia Serano | transsexual American writer, … | 1967 |
| Victor Serge | Russian revolutionary and wri… | 1890–1947 |
| Rod Serling | American screenwriter | 1924–1975 |
| Nicholas Serota | British curator | 1946 |
| Namwali Serpell | Zambian feminist academic and… | 1980 |
| Richard Serra | American sculptor | 1939 |
| Ian Serraillier | British writer | 1912–1994 |
| Christian Serratos | American actress | 1990 |
| Jean-Pierre Serre | French mathematician | 1926 |
| Antonin Sertillanges | French philosopher | 1863–1948 |
| Ivan Van Sertima | British Africanist in New Jer… | 1935–2009 |
| Paul Sérusier | French painter | 1864–1927 |
| Michael Servetus | Spanish physician and theolog… | 1511–1553 |
| Robert W. Service | Canadian poet | 1874–1958 |
| Gabriel Serville | French politician | 1959 |
| Roy Sesana | Botswana activist | 1950 |
