| Budd Schulberg | American novelist and screenw… | 1914–2009 |
| Robert H. Schuller | American television evangelist | 1926–2015 |
| Sarah Schulman | American writer | 1958 |
| Tom Schulman | American film director, scree… | 1950 |
| Dutch Schultz | American mobster | 1902–1935 |
| Howard Schultz | | 1953 |
| Theodore Schultz | American economist | 1902–1998 |
| Harold M. Schulweis | American rabbi and theologian | 1925–2014 |
| Bruno Schulz | Polish novelist and painter | 1892–1942 |
| Charles M. Schulz | American cartoonist | 1922–2000 |
| Friedrich Wilhelm Schulz | German politician and publish… | 1797–1860 |
| E. F. Schumacher | British economist | 1911–1977 |
| Heinrich Christian Friedrich Schumacher | Danish scientist | 1757–1830 |
| Michael Schumacher | German racing driver | 1969 |
| Sandor Schuman | | |
| Robert Schumann | German composer, aesthete and… | 1810–1856 |
| Amy Schumer | American comedian and actor | 1981 |
| Chuck Schumer | U.S. Senator from the State o… | 1950 |
| Joseph Alois Schumpeter | Austrian economist | 1883–1950 |
| Frithjof Schuon | Swiss philosopher | 1907–1998 |
| Carl Schurz | Union Army general, politician | 1829–1906 |
| Kurt Schuschnigg | Chancellor of Austria | 1897–1977 |
| Arthur Schuster | Anglo-German physicist | 1851–1934 |
| Susan Polis Schutz | American poet | 1944 |
| Montgomery Schuyler | American architecture critic | 1843–1914 |
| Charles Schwab | Businessperson | 1937–1939 |
| Charles M. Schwab | American capitalist and publi… | 1862–1939 |
| Anna Schwartz | American economist | 1915–2012 |
| Barry Schwartz | American psychologist | 1946 |
| Delmore Schwartz | American poet | 1913–1966 |
| Jeffrey H. Schwartz | American anthropologist | 1948 |
| Laurent Schwartz | mathematician | 1915–2002 |
| Melvin Schwartz | American experimental physici… | 1932–2006 |
| Morrie Schwartz | American sociologist | 1916–1995 |
| Richard H. Schwartz | American mathematician and wr… | 1934 |
| Stephen Schwartz | American musical theatre lyri… | 1948 |
| Tony Schwartz | American writer | 1952 |
| Harry Schwarz | South African activist | 1924–2010 |
| John Henry Schwarz | American theoretical physicist | 1941 |
| Blake Schwarzenbach | American singer | 1967 |
| Arnold Schwarzenegger | actor, businessman and politi… | 1947 |
| Norman Schwarzkopf | United States Army general | 1934–2012 |
| Samanta Schweblin | Argentine writer | 1978 |
| Rusty Schweickart | American astronaut | 1935 |
| Albert Schweitzer | French-German physician, theo… | 1875–1965 |
| Peter Schweizer | American writer | 1964 |
| Julian Schwinger | American theoretical physicist | 1918–1994 |
| Kurt Schwitters | German artist | 1887–1948 |
| Dennis Sciama | British physicist | 1926–1999 |
| Céline Sciamma | French director and screenwri… | 1978 |
| Leonardo Sciascia | Italian writer | 1921–1989 |
| David Wheeler (computer scientist) | British computer scientist | 1927–2004 |
| Jeffrey Friedman (political scientist) | American political scientist | 1959 |
| Thomas Flanagan (political scientist) | author, academic, and politic… | 1944 |
| Paul Scofield | English actor | 1922–2008 |
| Martin Scorsese | American film director, scree… | 1942 |
| James I of Scotland | King of Scots | 1394–1437 |
| Mary, Queen of Scots | Scottish monarch and queen co… | 1542–1587 |
| Bon Scott | Rock musician | 1946–1980 |
| Cora L. V. Scott | American spiritualist, writer | 1840–1923 |
| C. P. Scott | British journalist, publisher… | 1846–1932 |
| Drew Scott | Canadian actor, realtor, and … | 1978 |
| Howard Scott | American engineer | 1890–1970 |
| James C. Scott | American political scientist … | 1936 |
| John Scott | British barrister and politic… | 1751–1838 |
| Kieran Scott | American writer | 1974 |
| Lizabeth Scott | American actress and singer | 1922–2015 |
| Mike Scott | songwriter, musician | 1958 |
| Rachel Scott | American murder victim | 1981–1999 |
| Ridley Scott | English film director and fil… | 1937 |
| Robert Falcon Scott | Royal Navy officer and explor… | 1868–1912 |
| Rose Scott | Australian suffragist | 1847–1925 |
| Susan Scott | | |
| Walter Scott | Scottish historical novelist,… | 1771–1832 |
| Walter Dill Scott | President of Northwestern uni… | 1869–1955 |
| Winfield Scott | Union United States Army gene… | 1786–1866 |
| W. Richard Scott | American sociologist | 1932 |
| Gil Scott-Heron | American musician, poet and a… | 1949–2011 |
| Lisa Scottoline | American writer | 1955 |
| Duns Scotus | Scottish Franciscan friar, ph… | 1265–1308 |
| Michael Andrew Screech | | 1926–2018 |
| Angus Scrimm | American actor | 1926–2016 |
| Skupina The Script | | |
| Christian Scriver | German hymnwriter | 1629–1693 |
| Roger Scruton | English philosopher | 1944–2020 |
| Marlan Scully | American physicist | 1939 |
| Matthew Scully | American political writer and… | 1959 |
| Vin Scully | American sports broadcaster | 1927 |
| Vincent Scully | American architectural histor… | 1920–2017 |
| Daniela Sea | American filmmaker, actor, an… | 1977 |
| Glenn T. Seaborg | American scientist | 1912–1999 |
| Jeremy Seabrook | British writer | 1939 |
| Sandra Seacat | American acting teacher and a… | 1936 |
| Bobby Seale | American activist | 1936 |
| Barbara Seaman | American journalist | 1935–2008 |
| Owen Seaman | Editor of Punch | 1861–1936 |
| John Rogers Searle | American philosopher | 1932 |
| Edmund Sears | American minister | 1810–1876 |
| Francis Sears | American physicist | 1898–1975 |
| James Sears | Canadian pickup artist, physi… | 1963 |
