| Norman Spinrad | American science fiction writ… | 1940 |
| African Spir | Russian philosopher | 1837–1890 |
| Henry Spira | American activist | 1927–1998 |
| Yannis Spiteris | Roman Catholic archbishop | 1947 |
| Eliot Spitzer | 54th Governor of New York | 1959 |
| Benjamin Spock | American pediatrician and aut… | 1903–1998 |
| Harriet Elizabeth Prescott Spofford | American author | 1835–1921 |
| Viola Spolin | American academic and acting … | 1906–1994 |
| Joel Spolsky | American blogger | 1965 |
| John Shelby Spong | American bishop | 1931 |
| Lysander Spooner | Anarchist, Entrepreneur, Abol… | 1808–1887 |
| Darius von Guttner Sporzynski | Historian | 1971 |
| Charles Sprague | Boston businessman and poet | 1791–1875 |
| Timothy Sprigge | British philosopher | 1932–2007 |
| Gardiner Spring | American clergyman | 1785–1873 |
| Jerry Springer | American television presenter… | 1944 |
| Nancy Springer | American author of fantasy, y… | 1948 |
| Dusty Springfield | English singer and record pro… | 1939–1999 |
| Tom Springfield | English musician, songwriter … | 1934 |
| Bruce Springsteen | American singer and songwriter | 1949 |
| Francis Spufford | British writer | 1964 |
| Charles Spurgeon | British preacher, author, pas… | 1834–1892 |
| Morgan Spurlock | American filmmaker, screenwri… | 1970 |
| Simon Spurrier | British comic writer | 1981 |
| Johanna Spyri | author of children's stories,… | 1827–1901 |
| J. C. Squire | British poet, writer, histori… | 1884–1958 |
| Bob Casey Sr. | American politician (1932-200… | 1932–2000 |
| David Jewett Waller, Sr. | Pennsylvanian minister and ci… | 1815–1893 |
| Donald Wills Douglas Sr. | American businessman | 1892–1981 |
| Edgar Bronfman, Sr. | Canadian-American businessman | 1929–2013 |
| Frank Bunker Gilbreth, Sr. | American industrial engineer | 1868–1924 |
| Henry Morgenthau, Sr. | American diplomat | 1856–1946 |
| Park Benjamin, Sr. | American journalist | 1809–1864 |
| Robert M. La Follette Sr. | American politician | 1855–1925 |
| Roy R. Grinker, Sr. | American psychiatrist and neu… | 1900–1993 |
| Piero Sraffa | Italian economist | 1898–1983 |
| Joseph Prathan Sridarunsil | Thai bishop | 1946 |
| Matthias Ssekamaanya | Ugandan Roman Catholic bishop | 1936 |
| Frits Staal | Dutch indologist | 1930–2012 |
| Dana Stabenow | American writer | 1952 |
| Walter Terence Stace | British civil servant, educat… | 1886–1967 |
| Ralph D. Stacey | | |
| Shannon Stacey | american writer | 1972 |
| George Stack | Irish Roman Catholic archbish… | 1946 |
| Jerry Stackhouse | American basketball player | 1974 |
| Michael A. Stackpole | science fiction author | 1957 |
| Walter P. Stacy | American judge | 1884–1951 |
| Friedrich Stadler | Austrian historian | 1951 |
| Anne Louise Germaine de Staël | Swiss author | 1766–1817 |
| Jerry Stahl | American writer | 1953 |
| Layne Staley | American singer | 1967–2002 |
| Joseph Stalin | General secretary of the Comm… | 1879–1953 |
| Megan Thee Stallion | American rapper and songwriter | 1995 |
| Richard Stallman | American software freedom act… | 1953 |
| Sylvester Stallone | American actor, screenwriter,… | 1946 |
| Aleksandar Stamboliyski | Bulgarian prime minister | 1879–1923 |
| Theodoros Stamos | American artist | 1922–1997 |
| Sebastian Stan | Romanian-American actor | 1982 |
| Tom Standage | British journalist | 1969 |
| Jill Stanek | American pro-life activist | 1956 |
| Jim Stanford | Canadian economist | 1961 |
| Franz Stangl | Austrian-born SS officer, com… | 1908–1971 |
| Doug Stanhope | American stand-up comedian, a… | 1967 |
| John A. Stankovic | | |
| Andy Stanley | American Christian minister | 1958 |
| Arthur Penrhyn Stanley | English churchman, Dean of We… | 1815–1881 |
| Bessie Anderson Stanley | American poet | 1879–1952 |
| Eric Stanley | | |
| Ginger Stanley | American model, actress and s… | 1931 |
| Henry Morton Stanley | Welsh journalist and explorer | 1841–1904 |
| Jason Stanley | American philosopher | 1969 |
| Jessamyn Stanley | American yoga teacher and aut… | 1987 |
| Thomas J. Stanley | American businessman | 1944–2015 |
| Andrés Stanovnik | Catholic archbishop | 1949 |
| Anita Stansfield | American writer | 1961 |
| Vivian Stanshall | English musician, artist and … | 1943–1995 |
| Benjamin Stanton | American politician | 1809–1872 |
| Brandon Stanton | American photographer | 1984 |
| Edwin M. Stanton | American lawyer, judge and po… | 1814–1869 |
| Elizabeth Cady Stanton | Suffragist and Women's Rights… | 1815–1902 |
| Harry Dean Stanton | American actor, musician, and… | 1926–2017 |
| Barbara Stanwyck | American actress | 1907–1990 |
| Richard Stanyhurst | | |
| Diederik Stapel | Dutch social psychologist | 1966 |
| Olaf Stapledon | British novelist and philosop… | 1886–1950 |
| John Stapp | American academic | 1910–1999 |
| Jeffree Star | American singer-songwriter, m… | 1985 |
| Achille Starace | Italian Fascist general | 1889–1945 |
| William H. Starbuck | American academic | 1934 |
| Philippe Starck | French architect and industri… | 1949 |
| Starhawk | American author, activist and… | 1951 |
| Becky Stark | American singer | 1976 |
| Don Stark | American actor | 1954 |
| Freya Stark | British explorer and writer | 1893–1993 |
| Pete Stark | American politician | 1931–2020 |
| Marion L. Starkey | American historian & writer | 1901–1991 |
| Jim Starlin | Comic creator | 1949 |
| Keir Starmer | British politician and barris… | 1962 |
| Jean Starobinski | Swiss writer | 1920–2019 |
| Szymon Starowolski | Polish historian | 1588–1656 |
