Eric R. Kandel Quotes

Eric Richard Kandel is an Austrian-American neuroscientist and a University Professor of biochemistry and biophysics at the College of Physicians and Surgeons at Columbia University. He was a recipient of the 2000 Nobel Prize in Physiology or Medicine for his research on the physiological basis of memory storage in neurons. He shared the prize with Arvid Carlsson and Paul Greengard.

Kandel, who had studied psychoanalysis, wanted to understand how memory works. Following the advice of his mentor Harry Grundfest, Kandel pursued a reductionist approach to studying the nervous system, searching for subject animals with large and basic neural structures. Kandel made his most famous breakthrough working with the sea slug Aplysia californica, which has large nerve cells amenable to experimental manipulation and is a member of the simplest group of animals known to be capable of learning.

He is a Senior Investigator in the Howard Hughes Medical Institute. He was also the founding director of the Center for Neurobiology and Behavior, which is now the Department of Neuroscience at Columbia University. He currently serves on the Scientific Council of the Brain & Behavior Research Foundation. Kandel's popularized account chronicling his life and research, In Search of Memory: The Emergence of a New Science of Mind, was awarded the 2006 Los Angeles Times Book Award for Science and Technology.

✵ 7. November 1929
Eric R. Kandel photo
Eric R. Kandel: 81   quotes 2   likes

Famous Eric R. Kandel Quotes

“Libet could predict what a person would do before the person was actually aware of having decided to do it.”

In Search of Memory (2006)
Context: By merely observing the electrical activity in the brain, Libet could predict what a person would do before the person was actually aware of having decided to do it. This finding caused philosophers of mind to ask: If the choice is determined in the brain before we decide to act, where is free will?... choice in action, as in perception, may reflect the importance of unconscious inference. Libet proposes that... just before the action is initiated, consciousness is recruited to approve or veto the action.

“What strategy does the brain use to read itself out?”

In Search of Memory (2006)
Context: What strategy does the brain use to read itself out? That question, which is central to the unitary nature of conscious experience, remains one of the many unresolved mysteries of the new science of mind.

“The Age of Insight is a product of my subsequent fascination with the intellectual history of Vienna from 1890 to 1918, as well as my interest in Austrian modernist art, psychoanalysis, art history, and the brain science that is my life's work. In this book I examine the ongoing dialogue between art and science that had its origins in fin-de-siècle Vienna…”

The Age of Insight (2012)
Variant: The Age of Insight is a product of my subsequent fascination with the intellectual history of Vienna from 1890 to 1918, as well as my interest in Austrian modernist art, psychoanalysis, art history, and the brain science that is my life's work. In this book I examine the ongoing dialogue between art and science that had its origins in fin-de-siècle Vienna...

Eric R. Kandel Quotes about memories

Eric R. Kandel Quotes about life

“CREB's opposing regulatory actions provide a threshold for memory storage, presumably to ensure that only important, life-serving experiences are learned. Repeated shocks to the tail are a significant learning experience for an Aplysia, just as, say, practicing the piano or conjugating French verbs are to us: practice makes perfect, repetition is necessary for long-term memory. In principle, however, a highly emotional state… could bypass the normal restraints on long-term memory.”

In Search of Memory (2006)
Context: CREB's opposing regulatory actions provide a threshold for memory storage, presumably to ensure that only important, life-serving experiences are learned. Repeated shocks to the tail are a significant learning experience for an Aplysia, just as, say, practicing the piano or conjugating French verbs are to us: practice makes perfect, repetition is necessary for long-term memory. In principle, however, a highly emotional state... could bypass the normal restraints on long-term memory. In such a situation, enough MAP kinase molecules would be sent into the nucleus rapidly enough to inactivate all of the CREB-2 molecules, thereby making it easy for protein kinase A to activate CREB-1 and put the experience directly into long-term memory.

“The life of a biological scientist in the United States is a life of discussion and debate—it is the Talmudic tradition writ large.”

In Search of Memory (2006)
Context: The life of a biological scientist in the United States is a life of discussion and debate—it is the Talmudic tradition writ large.... The egalitarian structure of American science encourages this camaraderie.... this would not—could not—have taken place in the Austria, the Germany, the France, or perhaps even the England of 1955.

Eric R. Kandel: Trending quotes

“Every time I embarked on a new course, there were well-meaning people… who advised against it.”

In Search of Memory (2006)
Context: I have at times felt alone, uncertain, without a well-trodden path to follow. Every time I embarked on a new course, there were well-meaning people... who advised against it. I had to learn early on to be comfortable with insecurity and to trust my own judgement on key issues.

Eric R. Kandel Quotes

“London taxi drivers have a larger hippocampus”

In Search of Memory (2006)
Context: Birds in which spatial memory is particularly important—those that store food at a large number of sites, for example—have larger hippocampuses than other birds.... London taxi drivers have a larger hippocampus than others the same age.... the size of their hippocampus continues to increase with time on the job.

“I owe my existence in the United States to the generosity of the Viennese Kultusgemeinde.”

In Search of Memory (2006)
Context: The Viennese Kultusgemeinde... was going bankrupt... European governments typically compensate Jewish agencies... but the Austrian government's compensation was not adequate.... I owe my existence in the United States to the generosity of the Viennese Kultusgemeinde.

“As astronomy and physics inspired the Enlightenment, so biology inspired Modernism.”

The Age of Insight (2012)
Context: As astronomy and physics inspired the Enlightenment, so biology inspired Modernism.... This new view led to a reexamination in art of the biological nature of human existence, as evident in Édouard Manet's Déjeuner sur l’Herbe... Manet's painting... reveals a theme... the complex relationship between the sexes and between fantasy and reality.... also startlingly modern because of its style. Several decades before Cézanne began to collapse three dimension into two, Manet here had already flattened the viewer's sense of perspective...

“Birds in which spatial memory is particularly important”

In Search of Memory (2006)
Context: Birds in which spatial memory is particularly important—those that store food at a large number of sites, for example—have larger hippocampuses than other birds.... London taxi drivers have a larger hippocampus than others the same age.... the size of their hippocampus continues to increase with time on the job.

“Unlike vision, touch, or smell, which are prewired and based on Kantian a priori knowledge, the spatial map presents us with a new type of representation, one based on a combination of a priori knowledge and learning.”

In Search of Memory (2006)
Context: Unlike vision, touch, or smell, which are prewired and based on Kantian a priori knowledge, the spatial map presents us with a new type of representation, one based on a combination of a priori knowledge and learning. The general capability for forming spatial maps is built into the mind, but the particular map is not. Unlike neurons in a sensory system, place cells are not switched on by sensory stimulation. Their collective activity represents the location where the animal thinks it is.

“The third great revolution, the Freudian revolution of Vienna 1900, revealed that we do not consciously control our own actions but are instead driven by unconscious motives. This… later led to the idea that human creativity… stems from conscious access to underlying, unconscious forces.”

The Age of Insight (2012)
Context: The Copernican revolution... revealed that the earth is not the center of the universe... The second, the Darwinian revolution... revealed that we are not created divinely or uniquely but instead evolved from simpler animals by a process of natural selection. The third great revolution, the Freudian revolution of Vienna 1900, revealed that we do not consciously control our own actions but are instead driven by unconscious motives. This... later led to the idea that human creativity... stems from conscious access to underlying, unconscious forces.

“As knowledge advances and scientific disciplines change, so do the disciplines impinging on them.”

Psychiatry, Psychoanalysis, and the New Biology of Mind (2008)

“Transferring the receptor from a social worm to a solitary worm makes the solitary worm social.”

In Search of Memory (2006)
Context: Cori Bargmann... has studied two variants of C. elegans... The only difference between the two is one amino acid in an otherwise shared receptor protein. Transferring the receptor from a social worm to a solitary worm makes the solitary worm social.

“The realization that our mental functioning is largely irrational was arrived at by several thinkers at the same time”

The Age of Insight (2012)
Context: The realization that our mental functioning is largely irrational was arrived at by several thinkers at the same time, including Friedrich Nietzsche... Freud, who was much influenced by both Darwin and Nietzsche... was its most profound and articulate exponent.... Schnitzler, Klimt, Kokoschka, and Schiele also discovered and explored new aspects of our unconscious mental life. They understood women better than Freud... and they saw more clearly than Freud the importance of an infant's bonding to its mother. They even realized the significance of the aggressive instinct earlier than Freud did.... Plato discussed unconscious knowledge... pointing out that much of our knowledge is inherent in the psyche in latent form.... Hermann von Helmholtz... advanced the idea that the unconscious plays a critical role in human visual perception.

“The remarkable insight that characterized Klimt's later work was contemporaneous with Freud's psychological studies and presaged the inward turn that would pervade all fields of inquiry”

The Age of Insight (2012)
Context: The remarkable insight that characterized Klimt's later work was contemporaneous with Freud's psychological studies and presaged the inward turn that would pervade all fields of inquiry in Vienna in 1900. This period... was characterized by the attempt to make a sharp break with the past and to explore new forms of expression in art, architecture, psychology, literature, and music. It spawned an ongoing pursuit to link these disciplines.

“It spawned an ongoing pursuit to link these disciplines.”

The Age of Insight (2012)
Context: The remarkable insight that characterized Klimt's later work was contemporaneous with Freud's psychological studies and presaged the inward turn that would pervade all fields of inquiry in Vienna in 1900. This period... was characterized by the attempt to make a sharp break with the past and to explore new forms of expression in art, architecture, psychology, literature, and music. It spawned an ongoing pursuit to link these disciplines.

“I outline in simple terms… our current understanding of the cognitive psychological and neurobiological basis of perception, memory, emotion, empathy, and creativity. …the principles of the viewer's response to art are applicable to all periods of painting.”

The Age of Insight (2012)
Context: I outline in simple terms... our current understanding of the cognitive psychological and neurobiological basis of perception, memory, emotion, empathy, and creativity.... the principles of the viewer's response to art are applicable to all periods of painting.

“Klimt sought newer truths that could not be captured by the camera. He… turned the artists view inward”

The Age of Insight (2012)
Context: Like other modern artists faced with the advent of the photography, Klimt sought newer truths that could not be captured by the camera. He... turned the artists view inward—away from the three-dimensional outside world and toward the multidimensional inner self and the unconscious mind.

“Even though I had long been taught that the genes of the brain are the governors of behavior, the absolute masters of our fate, our work showed that, in the brain as in bacteria, genes are also servants of the environment.”

In Search of Memory (2006)
Context: Even though I had long been taught that the genes of the brain are the governors of behavior, the absolute masters of our fate, our work showed that, in the brain as in bacteria, genes are also servants of the environment.... An environmental stimulus... activates modulatory interneurons that release serotonin. The serotonin acts on the sensory neuron to increase cyclic AMP and to cause protein kinase A and MAP kinase to move to the nucleus and activate CREB. The activation of CREB, in turn, leads to the expression of genes that changes the function and the structure of the cell.

Similar authors

Toni Morrison photo
Toni Morrison 184
American writer
Albert A. Michelson photo
Albert A. Michelson 5
American physicist
Tennessee Williams photo
Tennessee Williams 139
American playwright
Robert Fulghum photo
Robert Fulghum 82
American writer
Robert Frost photo
Robert Frost 265
American poet
Neale Donald Walsch photo
Neale Donald Walsch 69
American writer
M. Scott Peck photo
M. Scott Peck 26
American psychiatrist
Martin Lewis Perl photo
Martin Lewis Perl 9
American scientist
John Steinbeck photo
John Steinbeck 366
American writer
Theodore Schultz photo
Theodore Schultz 15
American economist