Amazing Fantasy #15 (August 1962) – The first Spider-Man story.
In later stories and adaptations, including the 2002 movie, this has appeared as "With great power comes great responsibility."
The saying pre-dates Amazing Fantasy. The phrase "with great power goes great responsibility" was spoken by J. Hector Fezandie in an 1894 graduation address at The Stevens Institute of Technology - "The Moral Influence of a Scientific Education", The Stevens Indicator, Volume 11, Page 217. The exact phrase was repeated during a speech by President Harry S. Truman in November 1950 - Public Papers of the Presidents of the United States: Harry S. Truman, 6666 (published 1965), Page 703. A UK Member of Parliament implied in 1817 that a variant of it was already a cliché ([1817, 1227, Parliamentary Debates, Thomas C. Hansard, http://books.google.co.uk/books?lr=&output=text&as_brr=0&as_drrb_is=b&as_minm_is=0&as_miny_is=&as_maxm_is=0&as_maxy_is=1850&id=B6w9AAAAcAAJ&dq=%22great-power+*+great-responsibility%22&q=%22%22that%2Bthe%2Bpossession%2Bof%2Bgreat%2Bpower%2Bnecessarily%2Bimplies%2Bgreat%2Bresponsibility%22%26hl%3Den%26sa%3DX%26ei%3DYX5WUqnYGaiO4wT9poCwBQ%26ved%3D0CDMQ6wEwAA%23v%3Donepage%26q%3D%22that+the+possession+of+great+power+necessarily+implies+great+responsibility%22%26f%3Dfalse%22#v=onepage&q=%22%22that%2Bthe%2Bpossession%2Bof%2Bgreat%2Bpower%2Bnecessarily%2Bimplies%22&f=false, October 10, 2013, He should, however, beg leave to remind the conductors of the press of their duty to apply to themselves a maxim which they never neglected to urge on the consideration of government—" that the possession of great power necessarily implies great responsibility."] The editor is quoting William Lamb (pp. 1125–1229)). The sentiment is also found in Luke 12:48: "from the one who has been entrusted with much, much more will be asked" (NIV).
