“Don't be afraid to be some one that they don't know how to handle.”
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“Don't worry. I've been in showbusiness for a long time now - I know how to handle bastards”
And Another Thing... (2009), Chapter 8

“What's better: to not be afraid or to know that you can handle being afraid?”
Other

As quoted in BBC interview with David Wigg (8 May 1969) http://web.archive.org/web/20080121033938/http://www.geocities.com/~beatleboy1/db1969.0508.beatles.html
Context: That's part of our policy, is not to be taken seriously, because I think our opposition, whoever they may be, in all their manifest forms, don't know how to handle humor. You know, and we are humorous, we are, what are they, Laurel and Hardy. That's John and Yoko, and we stand a better chance under that guise, because all the serious people, like Martin Luther King, and Kennedy, and Gandhi, got shot.

While My Guitar Gently Weeps (1968)
Lyrics

“Our humans
don't know how to talk to one another.”
"An Unexpected Meeting"
Poems New and Collected (1998), Salt (1962)
Context: Our snakes have shed their lightning,
our apes their flights of fancy,
our peacocks have renounced their plumes.
The bats flew out of our hair long ago. We fall silent in mid-sentence,
all smiles, past help.
Our humans
don't know how to talk to one another.