“Before the next century is over, human beings will no longer be the most intelligent of capable type of entity on the planet.”

Variant: Fransisco, what's the most depraved type of human being?

-The man without purpose.
Source: Atlas Shrugged

Philosophiae Naturalis Principia Mathematica (1687), Scholium Generale (1713; 1726)
Source: The Principia: Mathematical Principles of Natural Philosophy
Context: This most beautiful System of the Sun, Planets and Comets, could only proceed from the counsel and dominion of an intelligent and powerful being. And if the fixed Stars are the centers of other like systems, these being form'd by the like wise counsel, must be all subject to the dominion of One; especially, since the light of the fixed Stars is of the same nature with the light of the Sun, and from every system light passes into all the other systems. And lest the systems of the fixed Stars should, by their gravity, fall on each other mutually, he hath placed those Systems at immense distances one from another.

Strange Horizons interview (2008)

Jean Vanier: Philosopher.. http://www.independent.co.uk/news/people/jean-vanier-philosopher-who-dislikes-the-religion-of-success-wins-12m-templeton-prize-for-promoting-spiritual-awareness-10101621.html The Independent, 11 March 2015
From interviews and talks

1960s, Freedom From The Known (1969)
Context: I think there is a difference between the human being and the individual. The individual is a local entity, living in a particular country, belonging to a particular culture, particular society, particular religion. The human being is not a local entity. He is everywhere. If the individual merely acts in a particular corner of the vast field of life, then his action is totally unrelated to the whole. So one has to bear in mind that we are talking of the whole not the part, because in the greater the lesser is, but in the lesser the greater is not. The individual is the little conditioned, miserable, frustrated entity, satisfied with his little gods and his little traditions, whereas a human being is concerned with the total welfare, the total misery and total confusion of the world.

Cited in: Robert Horvitz, 'a node for jack burnham' https://horvitz.multiplace.org/burnham/homepage.html.
Beyond Modern Sculpture, 1968

“Stupid ones!” Casker said.
Untouched by Human Hands (p. 75)
Short fiction, Untouched by Human Hands (1954)

Artificial intelligence: Should we be as terrified as Elon Musk and Bill Gates? http://zdnet.com/article/artificial-intelligence-should-we-be-as-terrified-as-elon-musk-and-bill-gates in ZDNet (20 October 2015)