“Before the Industrial Revolution all techniques in use were supported by very narrow epistemic bases. That is to say, the people who invented them did not have much of a clue as to why and how they worked. The pre-1750 world produced, and produced well. It made many path-breaking inventions. But it was a world of engineering without mechanics, iron-making without metallurgy, farming without soil science, mining without geology, water-power without hydraulics, dye-making without organic chemistry, and medical practice without microbiology and immunology. The main point to keep in mind here is that such a lack of an epistemic base does not necessarily preclude the development of new techniques through trial and error and simple serendipity. But it makes the subsequent wave of micro-inventions that adapt and improve the technique and create the sustained productivity growth much slower and more costly. If one knows why some device works, it becomes easier to manipulate and debug it, to adapt to new uses and changing circumstances. Above all, one knows what will not work and thus reduce the costs of research and experimentation.”

Joel Mokyr, " The knowledge society: Theoretical and historical underpinnings http://ehealthstrategies.comnehealthstrategies.comnxxx.ehealthstrategies.com/files/unitednations_mokyr.pdf." AdHoc Expert Group on Knowledge Systems, United Nations, NY. 2003.