Source: The Human Predicament: A Candid Guide to Life's Biggest Questions (2017), Introduction, p. 7
“Big questions get big answers.”
Life Story (1987, BBC)
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Francis Crick 16
British molecular biologist, biophysicist, neuroscientist; … 1916–2004Related quotes

From the 1997 television program Stephen Hawking's Universe http://www.pbs.org/wnet/hawking/html/home.html
Unsourced variant: All of my life, I have been fascinated by the big questions that face us, and have tried to find scientific answers to them. Perhaps that is why I have sold more books on physics than Madonna has on sex. This quote seems to combine the above sentence from Stephen Hawking's Universe with a statement from the Foreword to The Illustrated Brief History of Time: As Nathan Myhrvold of Microsoft (a former post-doc of mine) remarked: I have sold more books on physics than Madonna has on sex.

When asked "Given the chance, how would you change the world?" (Independent, 18 March 2005.)
Other quotes
Out Among the Big Things, st. 3.
Out Where the West Begins and Other Western Verses http://www.cowboypoetry.com/ac.htm#outbk (1917)

“Can I give them what they think they're going to get from me? That's always the big question.”
Screen Stories (November 1970)

“I guess I’ll do what everyone else does: get on with my life and forget the big questions.”
Source: Century Rain (2004), Chapter 41 (p. 606)

Linus' blog: Black and white, 2008-11-02, Torvalds, Linus, 2008-11-02 http://torvalds-family.blogspot.com/2008/11/black-and-white.html,
2000s, 2008

“The big question is whether you are going to be able to say a hearty yes to your adventure”