“We could not guess how different from us they (extraterrestrials) might be.”

— Carl Sagan , book Contact

Source: Contact (1985), Chapter 3 (p. 48)
Context: We could not guess how different from us they (extraterrestrials) might be. It was hard enough to guess the intentions of our elected representatives in Washington.

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Carl Sagan 365

American astrophysicist, cosmologist, author and science ed… 1934–1996

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“In general, we look for a new law by the following process: First we guess it. Then we – now don't laugh, that's really true. Then we compute the consequences of the guess to see what, if this is right, if this law that we guessed is right, to see what it would imply. And then we compare the computation results to nature, or we say compare to experiment or experience, compare it directly with observations to see if it works. If it disagrees with experiment, it's wrong. In that simple statement is the key to science. It doesn't make any difference how beautiful your guess is, it doesn't make any difference how smart you are, who made the guess, or what his name is. If it disagrees with experiment, it's wrong. That's all there is to it.”

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same passage in transcript: video http://www.youtube.com/watch?v=-2NnquxdWFk&t=16m46s
The Character of Physical Law (1965)
Variant: In general we look for a new law by the following process. First we guess it. Then we compute the consequences of the guess to see what would be implied if this law that we guessed is right. Then we compare the result of the computation to nature, with experiment or experience, compare it directly with observation, to see if it works. If it disagrees with experiment it is wrong. In that simple statement is the key to science. It does not make any difference how beautiful your guess is. It does not make any difference how smart you are, who made the guess, or what his name is – if it disagrees with experiment it is wrong. That is all there is to it.

“Insofar as our children resemble us, they are our most precious admirers, and insofar as they differ, they can be our most vehement distractors. From the beginning, we tempt them into imitation of us and long for what may be life's most profound compliment: their choosing to live according to our own system of values. Though many of us take pride in how different we are from our parents, we are endlessly sad at how different our children are from us.”

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