“If God had wanted us to be concerned for the plight of the toads, he would have made them cute and furry.”

Source: I Am America

1780s, Letter to Peter Carr (1787)
Context: He who made us would have been a pitiful bungler, if he had made the rules of our moral conduct a matter of science. For one man of science, there are thousands who are not. What would have become of them? Man was destined for society. His morality, therefore, was to be formed to this object. He was endowed with a sense of right and wrong, merely relative to this.

Source: The Trial (1920), Ch. 1

The quote, and its many variants, has been widely attributed to Franklin; however, there has never been an authoritative source for the quote, and research http://64.233.187.104/search?q=cache:4EV3RmSwk04J:listserv.dom.edu/cgi-bin/wa.exe%3FA2%3Dind0507%26L%3Dstumpers-l%26O%3DD%26P%3D31953+abbe+morellet+franklin+wine&hl=en&ct=clnk&cd=3 indicates that it is very likely a misquotation of Franklin's words regarding wine: "Behold the rain which descends from heaven upon our vineyards; there it enters the roots of the vines, to be changed into wine; a constant proof that God loves us, and loves to see us happy." (see sourced section above for a more extensive quotation of this passage from a letter to André Morellet), written in 1779.
Misattributed

A charitable Man, reported in Bartlett's Familiar Quotations, 10th ed. (1919).

The trial of Charles B. Reynolds for blasphemy (1887)
Context: I want you to understand what has been done in the world to force men to think alike. It seems to me that if there is some infinite being who wants us to think alike he would have made us alike. Why did he not do so? Why did he make your brain so that you could not by any possibility be a Methodist? Why did he make yours so that you could not be a Catholic? And why did he make the brain of another so that he is an unbeliever — why the brain of another so that he became a Mohammedan — if he wanted us all to believe alike?
After all, maybe Nature is good enough and grand enough and broad enough to give us the diversity born of liberty. Maybe, after all, it would not be best for us all to be just the same. What a stupid world, if everybody said yes to everything that everybody else might say.
The most important thing in this world is liberty. More important than food or clothes — more important than gold or houses or lands — more important than art or science — more important than all religions, is the liberty of man.

Address to Fiji Week celebrations, 7 October 2005 (excerpts)