“An invincible determination can accomplish almost anything and in this lies the great distinction between great men and little men.”
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Thomas Fuller 35
English churchman and historian 1608–1661Related quotes

“The truth is, that in favor of almost every sect, the names of some great men can be pronounced.”
The Great Infidels (1881)
Spectrum: From Right to Left in the World of Ideas (2005), Ch. 13. "The Vanquished Left, Eric Hobsbawm" (2002)

Ten Sermons of Religion (1853), III : Of Justice and the Conscience https://en.wikisource.org/wiki/Ten_Sermons_of_Religion/Of_Justice_and_the_Conscience
Context: Justice is moral temperance in the world of men. It keeps just relations between men; one man, however little, must not be sacrificed to another, however great, to a majority, or to all men. It holds the balance betwixt nation and nation, for a nation is but a larger man; betwixt a man and his family, tribe, nation, race; between mankind and God. It is the universal regulator which coordinates man with man, each with all, — me with the ten hundred millions of men, so that my absolute rights and theirs do not interfere, nor our ultimate interests ever clash, nor my eternal welfare prove antagonistic to the blessedness of all or any one. I am to do justice, and demand that of all, — a universal human debt, a universal human claim.

Source: Dictionary of Burning Words of Brilliant Writers (1895), P. 105.

“A great man shows his greatness by the way he treats little men.”
Attributed to Carlyle in Dale Carnegie's How to Win Friends And Influence People (1936), but this quotation is not found in Carlyle's known works. The first mention found in Google Books dates from 1908, where the Rev. John Timothy Stone https://en.wikipedia.org/wiki/John_Timothy_Stone is quoted as claiming: 'The greatest critics of this world have been appreciators. Carlyle said, "You can discover a great man, or see a great man, by the way he treats little men.'
The quotation is subsequently found in slightly different forms, mostly in religious publications: "A great man shows his greatness by manner in which he treats little men" (1913, unattributed); The exact wording of Carnegie's quote suggests that it was taken from Stone's 1930 publication.
Disputed

“No sadder proof can be given by a man of his own littleness than disbelief in great men.”
1840s, Heroes and Hero-Worship (1840), The Hero as Divinity

“Great causes and little men go ill together.”
The Indian Annual Register Vol.1 (January-June 1939)

1955) as quoted in Albert Einstein: Historical and Cultural Perspectives (1997) ed. Gerald Holton, Yehuda Elkana, p. 388, from The Centennial Symposium in Jerusalem (1979
1950s