“Nature abhors a vacuum.”
Natura abhorret vacuum.
Chapter 5 http://books.google.com/books?id=tBROAAAAcAAJ&q=%22natura+abhorret+vacuum%22&pg=PA22#v=onepage.
Gargantua and Pantagruel (1532–1564), Gargantua (1534)
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Francois Rabelais 105
major French Renaissance writer 1494–1553Related quotes

“Nature abhors a vacuum, and I don’t like it much either.”
Source: Mindswap (1966), Chapter 32 (p. 153)

1940s–present, A Mencken Chrestomathy (1949)

United Nations General Assembly - Promotion of a democratic and equitable international order http://www.ohchr.org/Documents/Issues/IntOrder/A-68-284_en.pdf.
2013

Slaves of Time (p. 18)
Short fiction, The Robot Who Looked Like Me (1978)

Commentarius in VIII Libros Physicorum Aristoteles (c. 1230-1235)

“I am a leader by default, only because nature does not allow a vacuum.”
As quoted in The Christian Science Monitor (20 December 1984)

“Nature abhors the old, and old age seems the only disease; all others run into this one.”
1840s, Essays: First Series (1841), Circles
“Nature abhors imperfect work
And on it lays her ban;
And all creation must despise
A tailless man.”
Prehistoric Smith, reported in Bartlett's Familiar Quotations, 10th ed. (1919).