Source: Give Me Liberty! (1998), Ch. 17 : Success Redefined, p. 178
Context: The new and most powerful union of all will be a union of one — one man, one woman, one worker with special skills, an inquiring mind, and an independent attitude, his creativity intact, his love of life blooming. The union of one will be peopled by one man or one woman who is alive. Such a person is always sought by the intelligent manager.
“One special advantage of the skeptical attitude of mind is that a man is never vexed to find that after all he has been in the wrong.”
The Treatment of Disease Can Lancet 1909;42:899-912.
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William Osler 50
Canadian pathologist, physician, educator, bibliophile, his… 1849–1919Related quotes

1940s, "Autobiographical Notes" (1949)
Context: Even when I was a fairly precocious young man the nothingness of the hopes and strivings which chases most men restlessly through life came to my consciousness with considerable vitality. Moreover, I soon discovered the cruelty of that chase, which in those years was much more carefully covered up by hypocrisy and glittering words than is the case today. By the mere existence of his stomach everyone was condemned to participate in that chase. Moreover, it was possible to satisfy the stomach by such participation, but not man in so far as he is a thinking and feeling being. As the first way out there was religion, which is implanted into every child by way of the traditional education-machine. Thus I came—despite the fact that I was the son of entirely irreligious (Jewish) parents—to a deep religiosity, which, however, found an abrupt ending at the age of 12. Through the reading of popular scientific books I soon reached the conviction that much in the stories of the Bible could not be true. The consequence was a positively fanatic [orgy of] freethinking coupled with the impression that youth is intentionally being deceived by the state through lies; it was a crushing impression. Suspicion against every kind of authority grew out of this experience, a skeptical attitude towards the convictions which were alive in any specific social environment—an attitude which has never again left me, even though later on, because of a better insight into the causal connections, it lost some of its original poignancy.
1890
The Philosophical Emperor, a Political Experiment, or, The Progress of a False Position: (1841)
Context: Man soon finds what he wants to find. If he cannot find it otherwise, he creates it for his special enjoyment: for instance, if a man wants to see a ghost, he need only promulge his wish some night around a decaying fire, with a few alarmed and shocked listeners. Then let him ascend in the dark to a remote chamber, carefully looking over his shoulder every few moments; and if he will not see a ghost, he will feel as if he saw one, and that will be tantamount thereto.

“The fool has one great advantage over a man of sense — he is always satisfied with himself.”
Napoleon : In His Own Words (1916)

Marginalia http://www.easylit.com/poe/comtext/prose/margin.shtml (November 1844)