“Experimental science is a craft and an art, and part of the art is knowing when to end a fruitless experiment. There is a danger of becoming obsessed with a fruitless experiment even if it goes nowhere.”
Nobel prize lecture
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Martin Lewis Perl 9
American scientist 1927–2014Related quotes

(15 June 2007)
Unfit for Mass Consumption (blog entries), 2007
Context: Art is not science. Even when art is about science, it is still art. There cannot be consensus, in the sense that science strives for meaningful consensus. And unlike science, art is not progressive. Personally, I have my doubts that science can be said to be genuinely progressive, but I'm pretty dammed certain that art is not. Which is not to say that it is not accumulative or accretionary. But the belief that sf writers are out there forecasting the future, that they have some social responsibility to do so, that's malarky, if you ask me. Writers of sf can only, at best, make educated guesses, and usually those guesses are wrong, and clumping together to form a consensus does not in any way insure against history unfolding in one of those other, unpredicted directions. People love to pick out the occasional instances where Jules Verne and William Gibson got it right; they rarely ever point fingers at their miscalls.
The Paris Review interview (1958)
Context: The perfect ideal would be that a man who is essentially nonviolent would be able to defend himself against any form of violence. But this is very rare in life. But this raises one of the most important themes in Eternity, why Prewitt does not shoot back at the MPs who kill him as he tries to get back to his unit after his murder of Fatso Judson. You see, when Prewitt kills Fatso he is carrying the theory of vengeance by violence to its final logical end. But the thing is that Fatso doesn't even know why he is being killed; and when Prewitt sees that, he realizes what a fruitless thing he has done.

Source: Elizabeth Day Damien Hirst: 'Art is childish and childlike' http://www.theguardian.com/theobserver/2010/sep/26/damien-hirst-art, The Guardian, 26 September 2010

Letter to his wife, reprinted in Rilke’s Letters on Cézanne (1952, trans. 1985). (June 24, 1907)
Rilke's Letters
Ch 20
A Canticle for Leibowitz (1959), Fiat Lux
Context: Reasoning which touches experimental reality nowhere is the business of angelologists and theologians, not of physical scientists. And yet such papers as these describe systems which touch our experience nowhere. Were they within the experimental reach of the ancients? Certain references tend to indicate it. One paper refers to elemental transmutation — which we just recently established as theoretically impossible — and then it says — 'experiment proves.' But how?
It may take generations to evaluate and understand some of these things. It is unfortunate that they must remain here in this inaccessible place, for it will take a concentrated effort by numerous scholars to make meaning of them.

“And this [experimental] science verifies all natural and man-made things in particular, and in their appropriate discipline, by the experimental perfection, not by arguments of the still purely speculative sciences, nor through the weak, and imperfect experiences of practical knowledge. And therefore, this is the matron of all preceding sciences, and the final end of all speculation.”
Et hæc scientia certificat omnia naturalia et artificialia in particulari et in propria disciplina, per experientiam perfectam; non per argumenta, ut scientiæ pure speculativae, nec per debiles et imperfecta experientias ut scientiae operativæ. Et ideo hæc est domina omnium scientiarum præcedentium, et finis totius speculationis.
Ch 13 ed. J. S. Brewer Opera quadam hactenus inedita (1859) p. 46
Opus Tertium, c. 1267

"Great Thought" (19 February 1938), published in The Notebooks of Raymond Chandler (1976)
Context: There are two kinds of truth: the truth that lights the way and the truth that warms the heart. The first of these is science, and the second is art. Neither is independent of the other or more important than the other. Without art, science would be as useless as a pair of high forceps in the hands of a plumber. Without science, art would become a crude mess of folklore and emotional quackery. The truth of art keeps science from becoming inhuman, and the truth of science keeps art from becoming ridiculous.