“A soul without reflection, like a pile
Without inhabitant, to ruin runs.”

Source: Gargantua and Pantagruel (1532–1564), Pantagruel (1532), Chapter 8 <!-- Thy father Gargantua. From Utopia the 17th day of the month of March. -->
Variant translation: Wisdom entereth not into a malicious mind, and science without conscience is but the ruin of the soul.
Original: Science sans conscience n'est que ruine de l'âme.
Context: But because, as the wise man Solomon saith, Wisdom entereth not into a malicious mind, and that knowledge without conscience is but the ruin of the soul, it behoveth thee to serve, to love, to fear God, and on him to cast all thy thoughts and all thy hope, and by faith formed in charity to cleave unto him, so that thou mayst never be separated from him by thy sins. Suspect the abuses of the world. Set not thy heart upon vanity, for this life is transitory, but the Word of the Lord endureth for ever. Be serviceable to all thy neighbours, and love them as thyself. Reverence thy preceptors: shun the conversation of those whom thou desirest not to resemble, and receive not in vain the graces which God hath bestowed upon thee.

Attributed to Cicero in J. M. Braude's Speaker's Desk Book of Quips, Quotes, & Anecdotes (Jaico Pub. House, 1966), p. 52.
Dennis McHenry in a 2011 post at theCAMPVS.com http://thecampvs.com/2011/08/03/cicero-on-books-and-the-soul/ identified a source for the exact form of words in the essay "On the Pleasure of Reading" http://books.google.com/books?id=0YfQAAAAMAAJ&dq=cicero%20%22room%20without%20books%22%20%2B%22contemporary%20review%22&pg=PA240#v=onepage&q&f=false by Sir John Lubbock, published in The Contemporary Review, vol. 49 (1886) https://archive.org/details/contemporaryrev55unkngoog, pp. 240–51 https://archive.org/stream/contemporaryrev55unkngoog#page/n250/mode/2up, in which Lubbock wrote that "Cicero described a room without books as a body without a soul" (p. 241). The same sentence may also be found on p. 61 https://archive.org/stream/thepleasuresofli01lubbuoft#page/60/mode/2up of Lubbock's collection The Pleasures of Life. Part I. 18th edition (London and New York : Macmillan and Co. 1890) https://archive.org/details/thepleasuresofli01lubbuoft, in a lecture titled "A Song of Books". McHenry suggested that Lubbock may have had in mind the words "postea vero quam Tyrannio mihi libros disposuit mens addita videtur meis aedibus" at Cicero, Ad Atticum 4.8, which are translated by E. O. Winstedt on p. 293 https://archive.org/stream/letterstoatticus01ciceuoft#page/292/mode/2up of Cicero: Letters to Atticus I (London : William Heinemann, and New York : G. P. Putnam's Sons 1912) https://archive.org/details/letterstoatticus01ciceuoft "Since Tyrannio has arranged my books, the house seems to have acquired a soul", and by Evelyn Shuckburgh on p. 234 https://archive.org/stream/cu31924012541433#page/n283/mode/2up of The Letters of Cicero. Vol. I. B. C. 68–52 (London : George Bell and Sons 1908) https://archive.org/details/cu31924012541433 "Moreover, since Tyrannio has arranged my books for me, my house seems to have had a soul added to it" (although the Latin word " mens http://athirdway.com/glossa/?s=mens", rendered "soul" by both Winstedt and Shuckburgh, is more usually translated by the English "mind"). D. R. Shackleton Bailey in Cicero's Letters to Atticus (Harmondsworth : Penguin Books 1978), p. 162, translated "And now that Tyrannio has put my books straight, my house seems to have woken to life".
Disputed
Variant: Ut conclave sine libris ita corpus sine anima" A room without books is like a body without a soul

Source: The Bloody Chamber and Other Stories

Source: Dictionary of Burning Words of Brilliant Writers, P. 625.

Source: Divine Secrets of the Ya-Ya Sisterhood

The Duty of Owning Books (1859)
Context: Books are the windows through which the soul looks out. A house without books is like a room without windows. No man has a right to bring up his children without surrounding them with books, if he has the means to buy them. It is a wrong to his family. He cheats them! Children learn to read by being in the presence of books. The love of knowledge comes with reading and grows upon it.

Source: The Counterlife (1986), Ch. 5