“Many times, God speaks blessing and breakthrough through pain and disappointment.”

No. 117.
The Guardian (1713)

Can it alter the cause, or unravel the mystery of human events?
Misattributed to Tryon Edwards by a number of websites, thinkexist.com and quoteland.com among others. This quote does appear on p. 23 of Edwards' compilation, A Dictionary of Thoughts; however, it is clearly identified there as a quote by Hugh Blair, the Scottish author and preacher.
A genuine Tryon Edwards quote on the subject of anxiety appears above in the Sourced section ( from p. 22 of A Dictionary of Thoughts. )
Misattributed

Can it alter the cause, or unravel the mystery of human events?
Quoted in A Dictionary of Thoughts: Being a Cyclopedia of Laconic Quotations from the Best Authors of the World, Both Ancient and Modern, https://books.google.com/books?id=zlMxAAAAIAAJ ed. Tryon Edwards, F. B. Dickerson Company (1908), p. 23.

Source: Dictionary of Burning Words of Brilliant Writers (1895), P. 281.

Air Force One phone call https://web.archive.org/save/http://www.berkeleydailyplanet.com/issue/2002-10-25/article/15626?headline=Bush-praises-law-community-for-capturing-sniper-suspects--By-Ron-Fournier- to Charles A. Moose (24 October 2002), as quoted in "Bush Praises Law Community For Capturing Sniper Suspects" (25 October 2002), by Ron Fournier, Berkeley Daily Planet.
2000s, 2002

(A.J. Broomhall. Hudson Taylor and China’s Open Century, Book Five: Refiner’s Fire. London: Hodder and Stoughton and Overseas Missionary Fellowship, 1985, 406).

"I want everything" in What I Want from Life (1934) edited by Edmund George Cousins, p. 108
Context: The cynic says "blessed is he who expecteth nothing, for he shall not be disappointed." I say "blessed is he who expecteth everything, for he can't always be disappointed."

Aleph (2011)