“Physics is always a gamble; it is a game of exploration. That’s the fun of it. We never know for sure what will happen. Sometimes, we theorists can anticipate, but nature is the final judge.”

— David Gross

"Physics is always a gamble" http://www.thehindu.com/opinion/interview/nobel-laureate-david-gross-physics-is-always-a-gamble/article7383717.ece, an interview with David Gross by Shubashree Desikan, The Hindu (2015)

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David Gross 6

American particle physicist and string theorist 1941

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“I want to deal with one or two of these mighty precious values that we've left behind, that if we're to go forward and to make this a better world, we must rediscover. The first is this—the first principle of value that we need to rediscover is this: that all reality hinges on moral foundations. In other words, that this is a moral universe, and that there are moral laws of the universe just as abiding as the physical laws. I'm not so sure we all believe that. We never doubt that there are physical laws of the universe that we must obey. We never doubt that. And so we just don't jump out of airplanes or jump off of high buildings for the fun of it—we don't do that. Because we unconsciously know that there is a final law of gravitation, and if you disobey it you'll suffer the consequences—we know that. Even if we don't know it in its Newtonian formulation, we know it intuitively, and so we just don't jump off the highest building in Detroit for the fun of it—we don't do that. Because we know that there is a law of gravitation which is final in the universe. (Lord) If we disobey it we'll suffer the consequences. But I'm not so sure if we know that there are moral laws just as abiding as the physical law. I'm not so sure about that. I'm not so sure if we really believe that there is a law of love in this universe, and that if you disobey it you'll suffer the consequences.”

Martin Luther King, Jr. (1929–1968) American clergyman, activist, and leader in the American Civil Rights Movement

1950s, Rediscovering Lost Values (1954)

“We all know the disappointments that come when we base anticipation on what we and other humans can deliver. God will never have a problem delivering!”

James MacDonald (1960) American pastor

Source: Always True (Moody, 2011), p. 89

“What we anticipate seldom occurs; what we least expected generally happens.”

Benjamin Disraeli (1804–1881) British Conservative politician, writer, aristocrat and Prime Minister

Book 2, chapter 4. Compare: "I say the very things that make the greatest Stir / An' the most interestin' things, are things that did n't occur", Sam Walter Foss, Things that did n't occur.
Books, Coningsby (1844), Henrietta Temple (1837)

“We always do what’s natural, only sometimes we shouldn’t do it.”

Alfred Bester book The Stars My Destination

Source: The Stars My Destination (1956), Chapter 6 (p. 98).

“What do we mean by “understanding” something? We can imagine that this complicated array of moving things which constitutes “the world” is something like a great chess game being played by the gods, and we are observers of the game. We do not know what the rules of the game are; all we are allowed to do is to watch the playing. Of course, if we watch long enough, we may eventually catch on to a few of the rules. The rules of the game are what we mean by fundamental physics.”

Richard Feynman (1918–1988) American theoretical physicist

Even if we knew every rule, however, we might not be able to understand why a particular move is made in the game, merely because it is too complicated and our minds are limited. If you play chess you must know that it is easy to learn all the rules, and yet it is often very hard to select the best move or to understand why a player moves as he does. So it is in nature, only much more so.
volume I; lecture 2, "Basic Physics"; section 2-1, "Introduction"; p. 2-1
The Feynman Lectures on Physics (1964)