Source: The Curious Incident of the Dog in the Night-Time
“To a great mind, nothing is little,' remarked Holmes, sententiously.”
Source: A Study in Scarlet
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Arthur Conan Doyle 166
Scottish physician and author 1859–1930Related quotes

Source: 1980s and later, "Why a diagram is (sometimes) worth ten thousand words," (1987), p. 65

On Horace Walpole (1833)

"Philip of Pokanoket : An Indian Memoir".
A more extensive statement not found as such in this work is attributed to Irving in Elbert Hubbard's Scrap Book (1923) edited by Roycroft Shop:
The Sketch Book of Geoffrey Crayon (1819–1820)
Variant: Little minds are tamed and subdued by misfortune; but great minds rise above it.

“Minds that have nothing to confer
Find little to perceive.”
Yes, Thou art Fair, Yet Be Not Moved, st. 2 (1845).

“Nothing is little to him that feels it with great sensibility.”
July 20, 1762
Life of Samuel Johnson (1791), Vol I