“It is only by poets that the life of any epoch can be synthesized. Encyclopaedias and guides to knowledge cannot do it, for the good reason that they affect only the intellectual surface of a man’s life. The lower layers, the core of his being, they leave untouched.”

“Objectivism's philosophy of man begins with the fact that man is a being of volitional consciousness: man is the one animal who has to choose to be conscious, to use his mind. Man is a rational animal, and reason is his only guide to knowledge, reason being that faculty which identifies and integrates the material provided by man's senses.”

“Life cannot be administered by definite rules and regulations; that wisdom to deal with a man’s difficulties comes only through some knowledge of his life and habits as a whole …”

“Only as a warrior can one withstand the path of knowledge. A warrior cannot complain or regret anything. His life is an endless challenge, and challenges cannot possibly be good or bad. Challenges are simply challenges.”

“The golden rule for understanding spiritually is not intellect, but obedience. If a man wants scientific knowledge, intellectual curiosity is his guide; but if he wants insight into what Jesus Christ teaches, he can only get it by obedience.”

“Ultimately, man should not ask what the meaning of his life is, but rather must recognize that it is he who is asked. In a word, each man is questioned by life; and he can only answer to life by answering for his own life; to life he can only respond by being responsible.”

“The philosophical anthropologist … can know the wholeness of the person and through it the wholeness of man only when he does not leave his subjectivity out and does not remain an untouched observer.”

“The good life is one inspired by love and guided by knowledge.”

“The only part of evolution in which any considerable interest is felt is evolution applied to man. A hypothesis in regard to the rocks and plant life does not affect the philosophy upon which one's life is built. Evolution applied to fish, birds and beasts would not materially affect man's view of his own responsibilities except as the acceptance of an unsupported hypothesis as to these would be used to support a similar hypothesis as to man. The evolution that is harmful— distinctly so — is the evolution that destroys man’s family tree as taught by the Bible and makes him a descendant of the lower forms of life. This … is a very vital matter.”

“A man cannot have a better guide than himself, nor any physic better than a regular life.”