Quotes from work
The Fusion of Broken Ends of Chromosomes Following Nuclear Fusion

Barbara McClintock
Barbara McClintock photo

“When, through radiation or other causes, chromosomes are broken within a single nucleus, 2-by-2 fusions may occur between the broken ends. These fusions may lead to rearrangements of parts of the chromatin complement, giving rise to various chromosomal aberrations which are detected as reciprocal translocations, inversions, deficiencies, etc. Since, in the well-investigated cases, the breakages occurred within a single nucleus, the conditions that lead to fusions of broken ends could not easily be ascertained.”

Barbara McClintock The Fusion of Broken Ends of Chromosomes Following Nuclear Fusion

[Proc Natl Acad Sci U S A, November 1942, 28, 11, 458–463, 10.1073/pnas.28.11.458, The Fusion of Broken Ends of Chromosomes Following Nuclear Fusion, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1078518/?page=1]

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