“Hopelessness is the root of anxiety, mental illness, and depression. It is the source of all misery and the cause of all addiction.”
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Mark Manson 50
American writer and blogger 1984Related quotes

“At the root of all misery is unfulfilled desire.”
Source: Hope for Hard Times
Source: From the Notebooks of Dr. Brain (2007), Chapter 2 “Facing the Ultimate Archenemy” (p. 57)

"James Tobin - Biographical" (1981)
Context: For me, growing up in the 1930s, the two motivations powerfully reinforced each other. The miserable failures of capitalist economies in the Great Depression were root causes of worldwide social and political disasters. The crisis triggered a fertile period of scientific ferment and revolution in economic theory.

“That to live by one man's will became the cause of all men's misery.”
Of the Lawes of Ecclesiastical Politie (1594), Book I, reported in Bartlett's Familiar Quotations, 10th ed. (1919).