“I have an essay with the title "Eyes in their Last Extremity".
The title comes from the suicide note of the short-story writer Akutagawa Ryunosuke… It is the phrase that pulls at me with the greatest strength.”

Japan, the Beautiful and Myself (1969)
Context: I have an essay with the title "Eyes in their Last Extremity".
The title comes from the suicide note of the short-story writer Akutagawa Ryunosuke... It is the phrase that pulls at me with the greatest strength. Akutagawa said that he seemed to be gradually losing the animal something known as the strength to live, and continued:
"I am living in a world of morbid nerves, clear and cold as ice... I do not know when I will summon up the resolve to kill myself. But nature is for me more beautiful than it has ever been before. I have no doubt that you will laugh at the contradiction, for here I love nature even when I am contemplating suicide. But nature is beautiful because it comes to my eyes in their last extremity."
Akutagawa committed suicide in 1927, at the age of thirty-five.
In my essay, "Eyes in their Last Extremity", I had to say: "How ever alienated one may be from the world, suicide is not a form of enlightenment. However admirable he may be, the man who commits suicide is far from the realm of the saint." I neither admire nor am in sympathy with suicide.

Banquets of the Black Widowers (1984), p. 27
General sources

"Introduction" to The Best of Isaac Asimov (1973)<!-- , p. ix -->
The Last Question (1956)
Context: "The Last Question" is my personal favorite, the one story I made sure would not be omitted from this collection. Why is it my favorite? For one thing I got the idea all at once and didn't have to fiddle with it; and I wrote it in white-heat and scarcely had to change a word. This sort of thing endears any story to any writer.
Then, too, it has had the strangest effect on my readers. Frequently someone writes to ask me if I can give them the name of a story, which they think I may have written, and tell them where to find it. They don't remember the title but when they describe the story it is invariably "The Last Question". This has reached the point where I recently received a long-distance phone call from a desperate man who began, "Dr. Asimov, there's a story I think you wrote, whose title I can't remember—" at which point I interrupted to tell him it was "The Last Question" and when I described the plot it proved to be indeed the story he was after. I left him convinced I could read minds at a distance of a thousand miles.
No other story I have written has anything like this effect on my readers — producing at once an unshakeable memory of the plot and an unshakeable forgettery of the title and even author. I think it may be that the story fills them so frighteningly full, that they can retain none of the side-issues.

Quote in Max Ernst, Gonthier-Seghers, Paris, 1959; as cited in Max Ernst sculpture, Museo d'arte contemporanea. Edizioni Charta, Milano, 1996, p. 37
1951 - 1976

Response to Harlan Ellison, at a suggestion to work together on a story, as quoted by Ellison in his introduction to "The Human Operators" in Partners in Wonder (2014)

The Paris Review interview (2010)

"The greatest honor history can bestow is the title of peacemaker" was later used as Nixon's epitaph.
1960s, First Inaugural Address (1969)
Context: What kind of nation we will be, what kind of world we will live in, whether we shape the future in the image of our hopes, is ours to determine by our actions and our choices.
The greatest honor history can bestow is the title of peacemaker. This honor now beckons America — the chance to help lead the world at last out of the valley of turmoil, and onto that high ground of peace that man has dreamed of since the dawn of civilization.
If we succeed, generations to come will say of us now living that we mastered our moment, that we helped make the world safe for mankind.
This is our summons to greatness.