“I slowly became disillusioned with the reductionist ideal of physics, for it was completely clear that the outcome of these experiments was almost always impossible to predict from first principles, yet was right and meaningful and certainly regulated by the same microscopic laws that work in atoms.”

—  Robert B. Laughlin

On his education at MIT.
Nobel Prize autobiography (1998)
Context: I learned about X-ray diffraction, neutron scattering, raman scattering, infrared absorption spectroscopy, heat capacity, transport, time-dependent transport, magnetic resonance, electron diffraction, electron energy loss spectroscopy — all the experimental techniques that constitute the eyes and ears of modern solid state physics. As this occurred I slowly became disillusioned with the reductionist ideal of physics, for it was completely clear that the outcome of these experiments was almost always impossible to predict from first principles, yet was right and meaningful and certainly regulated by the same microscopic laws that work in atoms. Only many years later did I finally understand that this truth, which seems so natural to solid state physicists because they confront experiments so frequently, is actually quite alien to other branches of physics and is vigorously repudiated by many scientists on the grounds that things not amenable to reductionist thinking are not physics.

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Robert B. Laughlin 14
American physicist 1950

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