“Lastly, and doubtless always, but particularly at the end of the last century, certain scholars considered that since the appearances on our scale were finally the only important ones for us, there was no point in seeking what might exist in an inaccessible domain. I find it very difficult to understand this point of view since what is inaccessible today may become accessible tomorrow (as has happened by the invention of the microscope), and also because coherent assumptions on what is still invisible may increase our understanding of the visible.”

— Jean Baptiste Perrin

Nobel Lecture (11 December 1926) http://nobelprize.org/nobel_prizes/physics/laureates/1926/perrin-lecture.html

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