“As scientific men we have all, no doubt, felt that our fellow men have become more and more satisfying as fish have taken up their work which has been put often to base uses, which must lead to disaster. But what sin is to the moralist and crime to the jurist so to the scientific man is ignorance. On our plane knowledge and ignorance are the immemorial adversaries.
Scientific men can hardly escape the charge of ignorance with regard to the precise effect of the impact of modern science upon the mode of living of the people and upon their civilisation. For them, such a charge is worse than that of crime.”

— Frederick Soddy

Frederick Soddy's speech at the Nobel Banquet in Stockholm (10 December 1922) http://nobelprize.org/nobel_prizes/chemistry/laureates/1921/soddy-speech.html

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Frederick Soddy 3

chemist and physicist from England 1877–1956

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“All scientific work is incomplete – whether it be observational or experimental. All scientific work is liable to be upset or modified by advancing knowledge. That does not confer upon us a freedom to ignore the knowledge we already have, or to postpone the action that it appears to demand at a given time.”

Austin Bradford Hill (1897–1991) English epidemiologist and statistician

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“Some of the evils which are caused by the fallacy of an incompatibility between theory and practice having been described, it must now be admitted, that at the present time those evils show a decided tendency to decline. The extent of intercourse, and of mutual assistance, between men of science and men of practice, the practical knowledge of scientific men, and the scientific knowledge of practical men, have been for some time steadily increasing; and that combination and harmony of theoretical and practical knowledge—that skill in the application of scientific principles to practical purposes, which in former times was confined to a few remarkable individuals, now tends to become more generally diffused.”

William John Macquorn Rankine (1820–1872) civil engineer

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“We do not have a complete and satisfying knowledge of the world. We are reduced to the simple conclusion that everywhere in the world there is life like ourselves and that all life is shrouded in mystery. A true acquaintance with the world consists in being filled with a sense of the mystery of existence and life. This mystery becomes only more mysterious with every advance in scientific research. To be filled with the mystery of life is like that which is called in the language of mysticism the "wise ignorance," an ignorance which is nonetheless knowledge of the essential.”

Albert Schweitzer (1875–1965) French-German physician, theologian, musician and philosopher

Source: The Spiritual Life (1947), p. 304

“Our scientific power has outrun our spiritual power. We have guided missiles and misguided men.”

Martin Luther King, Jr. book Strength to Love

Strength to Love, Chapter 7
1960s, Strength to Love (1963)
Context: The means by which we live have outdistanced the ends for which we live. Our scientific power has outrun our spiritual power. We have guided missiles and misguided man.

“We have found it of paramount importance that in order to progress we must recognize our ignorance and leave room for doubt. Scientific knowledge is a body of statements of varying degrees of certainty — some most unsure, some nearly sure, but none absolutely certain.”

Richard Feynman (1918–1988) American theoretical physicist

The Value of Science (1955)
Context: The scientist has a lot of experience with ignorance and doubt and uncertainty, and this experience is of very great importance, I think. When a scientist doesn’t know the answer to a problem, he is ignorant. When he has a hunch as to what the result is, he is uncertain. And when he is pretty darn sure of what the result is going to be, he is still in some doubt. We have found it of paramount importance that in order to progress we must recognize our ignorance and leave room for doubt. Scientific knowledge is a body of statements of varying degrees of certainty — some most unsure, some nearly sure, but none absolutely certain. Now, we scientists are used to this, and we take it for granted that it is perfectly consistent to be unsure, that it is possible to live and not know. But I don’t know whether everyone realizes this is true. Our freedom to doubt was born out of a struggle against authority in the early days of science. It was a very deep and strong struggle: permit us to question — to doubt — to not be sure. I think that it is important that we do not forget this struggle and thus perhaps lose what we have gained.

“We begin to wonder if it is due to the fact that we don't know enough. But it can't be that. Because in terms of accumulated knowledge we know more today than men have known in any period of human history. We have the facts at our disposal. We know more about mathematics, about science, about social science, and philosophy than we've ever known in any period of the world's history. So it can't be because we don't know enough. And then we wonder if it is due to the fact that our scientific genius lags behind. That is, if we have not made enough progress scientifically. Well then, it can't be that. For our scientific progress over the past years has been amazing.”

Martin Luther King, Jr. (1929–1968) American clergyman, activist, and leader in the American Civil Rights Movement

1950s, Rediscovering Lost Values (1954)
Context: There is something wrong with our world, something fundamentally and basically wrong. I don't think we have to look too far to see that. I'm sure that most of you would agree with me in making that assertion. And when we stop to analyze the cause of our world's ills, many things come to mind. We begin to wonder if it is due to the fact that we don't know enough. But it can't be that. Because in terms of accumulated knowledge we know more today than men have known in any period of human history. We have the facts at our disposal. We know more about mathematics, about science, about social science, and philosophy than we've ever known in any period of the world's history. So it can't be because we don't know enough. And then we wonder if it is due to the fact that our scientific genius lags behind. That is, if we have not made enough progress scientifically. Well then, it can't be that. For our scientific progress over the past years has been amazing. Man through his scientific genius has been able to dwarf distance and place time in chains, so that today it's possible to eat breakfast in New York City and supper in London, England. Back in about 1753 it took a letter three days to go from New York City to Washington, and today you can go from here to China in less time than that. It can't be because man is stagnant in his scientific progress. Man's scientific genius has been amazing. I think we have to look much deeper than that if we are to find the real cause of man's problems and the real cause of the world's ills today. If we are to really find it I think we will have to look in the hearts and souls of men.

“The penalty for scientific irrelevance is, of course, that the statistician's work is ignored by the scientific community.”

George E. P. Box (1919–2013) British statistician

Source: Science and Statistics (1976), p. 798

“Hundreds of men have allowed their imagination to solve the universe, but the men who have contributed to our real understanding of natural phenomena have been those who were unstinting in their application of criticism to the product of their imaginations. It is such criticism which is the essence of the scientific use of the imagination, which is... the very life-blood of science.”

Karl Pearson book The Grammar of Science

Introductory
The Grammar of Science (1900)

“All sensations which have no direct reference to external objects, we are accustomed, as a matter of course, entirely to ignore, and we do not become aware of them till we make a scientific investigation of the action of the senses, or have our attention directed by illness to the phenomena of our own bodies.”

Hermann von Helmholtz (1821–1894) physicist and physiologist

"On the Physiological Causes of Harmony" (1857), p. 81
Popular Lectures on Scientific Subjects (1881)
Context: Now it is a universal law of the perceptions obtained through the senses that we pay only so much attention to the sensations actually experienced as is sufficient for us to recognise external objects. In this respect we are very one-sided and inconsiderate partisans of practical utility; far more so indeed than we suspect. All sensations which have no direct reference to external objects, we are accustomed, as a matter of course, entirely to ignore, and we do not become aware of them till we make a scientific investigation of the action of the senses, or have our attention directed by illness to the phenomena of our own bodies. Thus we often find patients, when suffering under a slight inflammation of the eyes, become for the first time aware of those beads and fibres known as mouches volantes swimming about within the vitreous humour of the eye, and then they often hypochondriacally imagine all sorts of coming evils, because they fancy that these appearances are new, whereas they have generally existed all their lives.

“The fuel on which science runs is ignorance. Science is like a hungry furnace that must be fed logs from the forests of ignorance that surround us. In the process, the clearing we call knowledge expands, but the more it expands, the longer its perimeter and the more ignorance comes into view.”

Matt Ridley book Genome

Source: Genome (1999), Chapter 20 “Politics” (p. 271)

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