“Clyde: I knew as soon as we got off the freeway, we'd run into trouble.”

Attributed to Bob Dole by Charlie Cook, "The Democrats' Wild Ride," Cook Political Report, (June 12, 2010)

Source: River Marked

Source: Last Sacrifice

"Where Desert Spirits Crowd the Night", p. 282
The Ivory and the Horn (1996)

Variant: The trouble with most of us is that we would rather be ruined by praise than saved by criticism
Source: The Power of Positive Thinking

On the experiment at University of Chicago which indicated a nuclear chain reaction was possible, as quoted in "Some Szilardisms on War, Fame, Peace", LIFE‎ magazine, Vol. 51, no. 9 (1 September 1961), p. 79
Variants:
We turned the switch, we saw the flashes, we watched them for about ten minutes — and then we switched everything off and went home. That night I knew the world was headed for sorrow...
As quoted in the Boston University Graduate Journal (1968)
We turned the switch, saw the flashes, watched for ten minutes, then switched everything off and went home. That night I knew the world was headed for sorrow.
As quoted in The Making Of The Atomic Bomb (1986) by Richard Rhodes
Context: All we had to do was lean back, turn a switch and watch a screen of a television tube. If flashes of light appeared on the screen it would mean that liberation of atomic energy would take place in our lifetime. We turned the switch, saw the flashes — we watched for about five minutes — then switched everything off and went home. That night I knew the world was headed for trouble.

Source: According to " Trump Manages To Give Some House GOPers More Heartburn In Hill Meeting http://talkingpointsmemo.com/dc/trump-changes-few-minds-with-meeting-on-the-hill" (July 7, 2016)

Source: Glimmerglass

Source: Lonesome Dove