“We're entering the most dangerous phase in the region in decades. I'm really not all that hopeful.”

A Testament (1957)

Source: Another Day

Me Talk Pretty One Day (2000)

Source: Go Ask Alice

Canto III, line 9.
Often quoted with the translated form "Abandon hope all ye who enter here". The word "all" modifies hope, not those who enter: "ogni speranza" means "all hope".
The Divine Comedy (c. 1308–1321), Inferno

Source: American Psycho (1991), p. 3; the opening of the book.
Context: ABANDON ALL HOPE YE WHO ENTER HERE is scrawled in blood red lettering on the side of the Chemical Bank near the corner of Eleventh and First and is in print large enough to be seen from the backseat of the cab as it lurches forward in the traffic leaving Wall Street and just as Timothy Price notices the words a bus pulls up, the advertisement for Les Miserables on its side blocking his view, but Price who is with Pierce & Pierce and twenty-six doesn't seem to care because he tells the driver he will give him five dollars to turn up the radio, "Be My Baby" on WYNN, and the driver, black, not American, does so.

Source: From Hell

1962, Rice University speech
Context: Many years ago the great British explorer George Mallory, who was to die on Mount Everest, was asked why did he want to climb it. He said, "Because it is there." Well, space is there, and we're going to climb it, and the moon and the planets are there, and new hopes for knowledge and peace are there. And, therefore, as we set sail we ask God's blessing on the most hazardous and dangerous and greatest adventure on which man has ever embarked.

As quoted in "Age of unreason" by Jeannette Baxter in The Guardian (22 June 2004)