“May those men who are animated by the true scientific spirit cease to believe that they are obliged to consider only subjects of public utility; …because, one must not hide it, the field of applications, so rich and fertile today, would not take long to be blighted by sterility if it ceased to be fertilized and revivified by the beneficial light which theoretical research radiates and pours incessantly upon it.”

As quoted in The Life and Science of Léon Foucault : The Man Who Proved the Earth Rotates (2003) by William Tobin, p. 93.

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Léon Foucault 5
French physicist 1819–1868

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James Clerk Maxwell (1831–1879) Scottish physicist

Introductory Lecture on Experimental Physics held at Cambridge in October 1871, re-edited by W. D. Niven (2003) in Volume 2 of The Scientific Papers of James Clerk Maxwell, Courier Dover Publications, p. 241; this has sometimes been misquoted in a way which considerably alters its intent: "in a few years, all the great physical constants will have been approximately estimated, and … the only occupation which will then be left to the men of science will be to carry these measurement to another place of decimals."
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But we have no right to think thus of the unsearchable riches of creation, or of the untried fertility of those fresh minds into which these riches will continue to be poured. It may possibly be true that, in some of those fields of discovery which lie open to such rough observations as can be made without artificial methods, the great explorers of former times have appropriated most of what is valuable, and that the gleanings which remain are sought after, rather for their abstruseness, than for their intrinsic worth. But the history of science shews that even during the phase of her progress in which she devotes herself to improving the accuracy of the numerical measurement of quantities with which she has long been familiar, she is preparing the materials for the subjugation of the new regions, which would have remained unknown if she had been contented with the rough methods of her early pioneers. I might bring forward instances gathered from every branch of science, shewing how the labour of careful measurement has been rewarded by the discovery of new fields of research, and by the development of new scientific ideas. But the history of the science of terrestrial magnetism affords us a sufficient example of what may be done by experiments in concert, such as we hope some day to perform in our Laboratory.

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“Any one who only knows scientific research in its practical applications may easily come to a wrong interpretation of the state of mind of the men who, surrounded by skeptical contemporaries, have shown the way to kindred spirits scattered over all countries in all centuries.”

Albert Einstein (1879–1955) German-born physicist and founder of the theory of relativity

Wording in Ideas and Opinions: It is therefore easy to see why the churches have always fought science and persecuted its devotees. On the other hand, I maintain that the cosmic religious feeling is the strongest and noblest motive for scientific research. Only those who realize the immense efforts and, above all, the devotion without which pioneer work in theoretical science cannot be achieved are able to grasp the strength of the emotion out of which alone such work, remote as it is from the immediate realities of life, can issue. What a deep conviction of the rationality of the universe and what a yearning to understand, were it but a feeble reflection of the mind revealed in this world, Kepler and Newton must have had to enable them to spend years of solitary labor in disentangling the principles of celestial mechanics! Those whose acquaintance with scientific research is derived chiefly from its practical results easily develop a completely false notion of the mentality of the men who, surrounded by a skeptical world, have shown the way to kindred spirits scattered wide through the world and through the centuries. Only one who has devoted his life to similar ends can have a vivid realization of what has inspired these men and given them the strength to remain true to their purpose in spite of countless failures. It is cosmic religious feeling that gives a man such strength. A contemporary has said, not unjustly, that in this materialistic age of ours the serious scientific workers are the only profoundly religious people.
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Context: It is, therefore, quite natural that the churches have always fought against science and have persecuted its supporters. But, on the other hand, I assert that the cosmic religious experience is the strongest and noblest driving force behind scientific research. No one who does not appreciate the terrific exertions, and, above all, the devotion without which pioneer creations in scientific thought cannot come into being, can judge the strength of the feeling out of which alone such work, turned away as it is from immediate practical life, can grow. What a deep faith in the rationality of the structure of the world and what a longing to understand even a small glimpse of the reason revealed in the world there must have been in Kepler and Newton to enable them to unravel the mechanism of the heavens in long years of lonely work! Any one who only knows scientific research in its practical applications may easily come to a wrong interpretation of the state of mind of the men who, surrounded by skeptical contemporaries, have shown the way to kindred spirits scattered over all countries in all centuries. Only those who have dedicated their lives to similar ends can have a living conception of the inspiration which gave these men the power to remain loyal to their purpose in spite of countless failures. It is the cosmic religious sense which grants this power. A contemporary has rightly said that the only deeply religious people of our largely materialistic age are the earnest men of research.

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Context: My purpose here is to denounce an idea which seems to be dangerous and false. … Revolutionary trade unionists and orthodox communists are at one in considering everything that is purely theoretical as bourgeois. … The culture of a socialist society would be a synthesis of theory and practice; but to synthesize is not the same as to confuse together; it is only contraries that can be synthesized. … Marx’s principal glory is to have rescued the study of societies not only from Utopianism but also and at the same time from empiricism. … Humanity cannot progress by importing into theoretical study the processes of blind routine and haphazard experiment by which production has so long been dominated. … The true relation between theory and application only appears when theoretical research has been purged of all empiricism.

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There's an earlier variant, without the memorable ending, that dates back to at least 1886:
I went at your bidding, and passed along their thoroughfares of trade. I ascended their mountains and went down their valleys. I visited their manufactories, their commercial markets, and emporiums of trade. I entered their judicial courts and legislative halls. But I sought everywhere in vain for the secret of their success, until I entered the church. It was there, as I listened to the soul-equalizing and soul-elevating principles of the Gospel of Christ, as they fell from Sabbath to Sabbath upon the masses of the people, that I learned why America was great and free, and why France was a slave.
Empty Pews & Selections from Other Sermons on Timely Topics, Madison Clinton Peters; Zeising, 1886, p. 35 http://books.google.com/books?id=f54PAAAAIAAJ&pg=PA35&dq=de+tochneville&ei=w1YCSbS3JoTkygS2g_mvDQ
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