“The method of guessing the equation seems to be a pretty effective way of guessing new laws”

— Richard Feynman , book The Character of Physical Law

The Character of Physical Law (1965)
Context: …Dirac discovered the correct laws for relativity quantum mechanics simply by guessing the equation. The method of guessing the equation seems to be a pretty effective way of guessing new laws. This shows again that mathematics is a deep way of expressing nature, and any attempt to express nature in philosophical principles, or in seat-of-the-pants mechanical feelings, is not an efficient way.

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Richard Feynman 181

American theoretical physicist 1918–1988

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“In general, we look for a new law by the following process: First we guess it. Then we – now don't laugh, that's really true. Then we compute the consequences of the guess to see what, if this is right, if this law that we guessed is right, to see what it would imply. And then we compare the computation results to nature, or we say compare to experiment or experience, compare it directly with observations to see if it works. If it disagrees with experiment, it's wrong. In that simple statement is the key to science. It doesn't make any difference how beautiful your guess is, it doesn't make any difference how smart you are, who made the guess, or what his name is. If it disagrees with experiment, it's wrong. That's all there is to it.”

Richard Feynman book The Character of Physical Law

same passage in transcript: video http://www.youtube.com/watch?v=-2NnquxdWFk&t=16m46s
The Character of Physical Law (1965)
Variant: In general we look for a new law by the following process. First we guess it. Then we compute the consequences of the guess to see what would be implied if this law that we guessed is right. Then we compare the result of the computation to nature, with experiment or experience, compare it directly with observation, to see if it works. If it disagrees with experiment it is wrong. In that simple statement is the key to science. It does not make any difference how beautiful your guess is. It does not make any difference how smart you are, who made the guess, or what his name is – if it disagrees with experiment it is wrong. That is all there is to it.