“If you want something you can have it, but only if you want everything that goes with it, including all the hard work and the despair, and only if you're willing to risk failure.”
Source: Clockwork
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Philip Pullman 161
English author 1946Related quotes
“You can only grow if you're willing to feel awkward and uncomfortable when you try something new.”

Address http://www.ted.com/talks/james_cameron_before_avatar_a_curious_boy.html/ to the 2010 TED conference (13 February 2010)
Context: Imagination is a force that can actually manifest a reality. … Don’t put limitations on yourself. Other people will do that for you. Don’t do that to yourself. Don’t bet against yourself. And take risk. NASA has this phrase that they like, "Failure is not an option." But failure has to be an option. In art and exploration, failure has to be an option. Because it is a leap of faith. And no important endeavour that required innovation was done without risk. You have to be willing to take those risks. … In whatever you are doing, failure is an option. But fear is not.

“If you want something you have never had, you must be willing to do something you have never done.”
Not found in Jefferson's writings, according to the Jefferson Monticello center https://www.monticello.org/site/research-and-collections/if-you-want-something-you-have-never-had-quotation. First known appearance in print is from 2004.
Misattributed

“You can only become great at something you are willing to sacrifice for”