“I submit respectfully to the House as a general principle that our responsibility in this matter is directly proportionate to our power. Where there is great power there is great responsibility, where there is less power there is less responsibility, and where there is no power there can, I think, be no responsibility.”

— Winston S. Churchill

In the House of Commons, February 28, 1906 speech South African native races http://hansard.millbanksystems.com/commons/1906/feb/28/south-african-native-races#S4V0152P0_19060228_HOC_307
Early career years (1898–1929)

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Winston S. Churchill 601

Prime Minister of the United Kingdom 1874–1965

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“WITH GREAT POWER THERE MUST ALSO COME--GREAT RESPONSIBILITY!”

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In later stories and adaptations, including the 2002 movie, this has appeared as "With great power comes great responsibility."
The saying pre-dates Amazing Fantasy. The phrase "with great power goes great responsibility" was spoken by J. Hector Fezandie in an 1894 graduation address at The Stevens Institute of Technology - "The Moral Influence of a Scientific Education", The Stevens Indicator, Volume 11, Page 217. The exact phrase was repeated during a speech by President Harry S. Truman in November 1950 - Public Papers of the Presidents of the United States: Harry S. Truman, 6666 (published 1965), Page 703. A UK Member of Parliament implied in 1817 that a variant of it was already a cliché ([1817, 1227, Parliamentary Debates, Thomas C. Hansard, http://books.google.co.uk/books?lr=&output=text&as_brr=0&as_drrb_is=b&as_minm_is=0&as_miny_is=&as_maxm_is=0&as_maxy_is=1850&id=B6w9AAAAcAAJ&dq=%22great-power+*+great-responsibility%22&q=%22%22that%2Bthe%2Bpossession%2Bof%2Bgreat%2Bpower%2Bnecessarily%2Bimplies%2Bgreat%2Bresponsibility%22%26hl%3Den%26sa%3DX%26ei%3DYX5WUqnYGaiO4wT9poCwBQ%26ved%3D0CDMQ6wEwAA%23v%3Donepage%26q%3D%22that+the+possession+of+great+power+necessarily+implies+great+responsibility%22%26f%3Dfalse%22#v=onepage&q=%22%22that%2Bthe%2Bpossession%2Bof%2Bgreat%2Bpower%2Bnecessarily%2Bimplies%22&f=false, October 10, 2013, He should, however, beg leave to remind the conductors of the press of their duty to apply to themselves a maxim which they never neglected to urge on the consideration of government—" that the possession of great power necessarily implies great responsibility."] The editor is quoting William Lamb (pp. 1125–1229)). The sentiment is also found in Luke 12:48: "from the one who has been entrusted with much, much more will be asked" (NIV).

“…the possession of great power necessarily implies great responsibility.”

William Lamb, 2nd Viscount Melbourne (1779–1848) British Whig statesman

Speech https://api.parliament.uk/historic-hansard/commons/1817/jun/27/habeas-corpus-suspension-bill#column_1227 in the House of Commons (27 June 1817)

“Great American power and responsibility are not unprecedented, and have been used with restraint and great benefit in the past.”

Jimmy Carter (1924) American politician, 39th president of the United States (in office from 1977 to 1981)

Post-Presidency, Nobel lecture (2002)
Context: The world has changed greatly since I left the White House. Now there is only one superpower, with unprecedented military and economic strength. The coming budget for American armaments will be greater than those of the next fifteen nations combined, and there are troops from the United States in many countries throughout the world. Our gross national economy exceeds that of the three countries that follow us, and our nation's voice most often prevails as decisions are made concerning trade, humanitarian assistance, and the allocation of global wealth. This dominant status is unlikely to change in our lifetimes.
Great American power and responsibility are not unprecedented, and have been used with restraint and great benefit in the past. We have not assumed that super strength guarantees super wisdom, and we have consistently reached out to the international community to ensure that our own power and influence are tempered by the best common judgment.
Within our country, ultimate decisions are made through democratic means, which tend to moderate radical or ill-advised proposals. Constrained and inspired by historic constitutional principles, our nation has endeavored for more than two hundred years to follow the now almost universal ideals of freedom, human rights, and justice for all.