“We often frame our understanding of what the space telescope will do in terms of what we expect to find, and actually it would be terribly anticlimactic if in fact we find what we expect to find. … The most important discoveries will provide answers to questions that we do not yet know how to ask and will concern objects we have not yet imagined.”
John N. Bahcall, quoted in his obituary at CalTech (7 September 2005) http://www.spitzer.caltech.edu/features/articles/20050907.shtml; On the Hubble Space Telescope's capabilities for the advancement of science
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John N. Bahcall 2
American physicist 1934–2005Related quotes

“We do not know what we want and yet we are responsible for what we are - that is the fact.”

“We often do not see what we do not expect to see”
Great Ideas in Physics : The Conservation of Energy, the Second Law of Thermodynamics, the Theory of Relativity, and Quantum Mechanics (2000), p. 4<!-- isbn=0071357386 -->
Context: The relationship between science and the humanities is two-way. Science changes our view of the world and our place in it. In the other direction, the humanities provide the store of ideas and images and language available to us in understanding the world. The exploding star of A. D. 1054, the Crab Nebula, was sighted and documented by the Chinese, but nowhere mentioned in the West, where the Aristotelian notion of the immortality of stars still held sway. We often do not see what we do not expect to see.

Quotations from Gurudev’s teachings, Chinmya Mission Chicago

Source: Self-Help; with Illustrations of Character and Conduct (1859), Ch. XI : Self-Culture — Facilities and Difficulties.
Source: The Lives Of George And Robert Stephenson
Context: We learn wisdom from failure much more than from success. We often discover what will do, by finding out what will not do; and probably he who never made a mistake never made a discovery.

“The fact that we have something is just what we would expect if there is no God.”
Source: God: The Failed Hypothesis (2007), Chapter 4: 'Cosmic Evidence', p.133
Context: The transition of nothing-to-something is a natural one, not requiring any agent. As Nobel laureate physicist Frank Wilczek has put it, "The answer to the ancient question 'Why is there something rather than nothing?' would then be that 'nothing' is unstable." [... ] In short, the natural state of affairs is something rather than nothing. An empty universe requires supernatural intervention--not a full one. Only by the constant action of an agent outside the universe, such as God, could a state of nothingness be maintained. The fact that we have something is just what we would expect if there is no God.

Quoted by Max Weber in his lecture "Science as a Vocation"; in Lynda Walsh (2013), Scientists as Prophets: A Rhetorical Genealogy (2013), Oxford University Press, p. 90

The Gold at the Starbow’s End (p. 349)
Platinum Pohl (2005)

If we do not, then we should look somewhere else.
Source: Books, Spiritual Warrior, Volume III: Solace for the Heart in Difficult Times (Hari-Nama Press, 2000), Chapter 8 - How To Strengthen Ourselves