“Yes, it is necessary to suffer, even in vain, so as not to live in vain.”

1790s

Source: Lady of Mazes (2005), Chapter 22 (p. 252).

Gegen die Langeweile kämpfen Götter selbst vergebens.
Sec. 48
The Antichrist (1888)
Source: The Anti-Christ

Letter to Gertrude Natkin, 2 March 1906 http://digitalcollections.nypl.org/items/53b4cf90-7739-0132-f12c-58d385a7b928

Aphorisms http://books.google.com/books?id=BeEnAAAAYAAJ&q="We+are+so+vain+that+we+value+the+opinion+even+of+those+whose+opinions+we+find+worthless".

Book II, Ch. 8 (Ch. 25 in editions without Book divisions): Dead London
The War of the Worlds (1898)
Context: For so it had come about, as indeed I and many men might have foreseen had not terror and disaster blinded our minds. These germs of disease have taken toll of humanity since the beginning of things — taken toll of our prehuman ancestors since life began here. But by virtue of this natural selection of our kind we have developed resisting power; to no germs do we succumb without a struggle, and to many — those that cause putrefaction in dead matter, for instance — our living frames are altogether immune. But there are no bacteria in Mars, and directly these invaders arrived, directly they drank and fed, our microscopic allies began to work their overthrow. Already when I watched them they were irrevocably doomed, dying and rotting even as they went to and fro. It was inevitable. By the toll of a billion deaths man has bought his birthright of the earth, and it is his against all comers; it would still be his were the Martians ten times as mighty as they are. For neither do men live nor die in vain.

Heretics and Heresies (1874)