“The question is—what is the question?”
Leonard Susskind, The Black Hole War (2008), chapter 13
John Archibald Wheeler was an American theoretical physicist. He was largely responsible for reviving interest in general relativity in the United States after World War II. Wheeler also worked with Niels Bohr in explaining the basic principles behind nuclear fission. Together with Gregory Breit, Wheeler developed the concept of the Breit–Wheeler process. He is best known for linking the term "black hole" to objects with gravitational collapse already predicted early in the 20th century, for coining the terms "quantum foam", "neutron moderator", "wormhole" and "it from bit", and for hypothesizing the "one-electron universe".
Wheeler earned his doctorate at Johns Hopkins University under the supervision of Karl Herzfeld, and studied under Breit and Bohr on a National Research Council fellowship. In 1939 he collaborated with Bohr to write a series of papers using the liquid drop model to explain the mechanism of fission. During World War II, he worked with the Manhattan Project's Metallurgical Laboratory in Chicago, where he helped design nuclear reactors, and then at the Hanford Site in Richland, Washington, where he helped DuPont build them. He returned to Princeton after the war ended, but returned to government service to help design and build the hydrogen bomb in the early 1950s.
For most of his career, Wheeler was a professor of physics at Princeton University, which he joined in 1938, remaining until his retirement in 1976. At Princeton he supervised 46 PhDs, more than any other professor in the Princeton physics department. Wikipedia

“The question is—what is the question?”
Leonard Susskind, The Black Hole War (2008), chapter 13
Scientific American (1992), Vol. 267.
As quoted by Amanda Gefter (from the symposium in honor of Wheeler's 90th birthday) [Trespassing on Einstein's lawn: a father, a daughter, the meaning of nothing, and the beginning of everything, 2014, https://books.google.com/books?id=NUMkAAAAQBAJ]
“… we can afford many mistakes in the search. The main thing is to make as fast as possible.”
As quoted by Charles W. Misner, Kip S. Thorne, and Wojciech H. Zurek. "John Wheeler, relativity, and quantum information." https://authors.library.caltech.edu/15184/1/Misner2009p1638Phys_Today.pdf Physics Today 62, no. 4 (April 2009): 40–46 (quote from p. 44) [10.1063/1.3120895]
“Spacetime tells matter how to move; matter tells spacetime how to curve.”
Wheeler's succinct summary of Einstein's theory of general relativity, in Geons, Black Holes, and Quantum Foam (2000), p. 235. http://books.google.com/books?id=zGFkK2tTXPsC&lpg=PA1&pg=PA235
As quoted by Paul Davies, Other Worlds (1980)
"The Anthropic Universe" http://www.abc.net.au/radionational/programs/scienceshow/the-anthropic-universe/3302686 (Feb 18, 2006) Australia's Science Show, with Martin Redfern moderating excerpts from several scientists, including Wheeler. Audio recording http://mpegmedia.abc.net.au/rn/podcast/2006/02/ssw_20060218_1200.mp3 and transcript available. See also same show at WayBack Machine, https://web.archive.org/web/20080616183602/http://www.abc.net.au/rn/science/ss/stories/s1572643.htm Internet archive.org.
[John Archibald Wheeler, Kenneth William Ford, Geons, Black Holes, and Quantum Foam: A Life in Physics, W. W. Norton & Company, 2000, 0393319911, 153]
As quoted in by Ken Wilber in Quantum Questions: Mystical Writings of the World's Great Physicists (2001) Shambhala, ISBN 1570627681.
"Information, Physics, Quantum: The Search for Links" in Complexity, Entropy and the Physics of Information (1990) ed., Wojciech H. Zurek, p. 5. http://books.google.com/books?id=mdjsOeTgatsC&lpg=PP1&pg=PA5
John Archibald Wheeler, in "Albert Einstein in Biographical Memoirs Vol. 51, by the National Academy of Sciences
“Time is nature's way to keep everything from happening all at once.”
Wheeler quoted this saying in Complexity, Entropy, and the Physics of Information (1990), p. 10 http://books.google.com/books?id=mdjsOeTgatsC&lpg=PP1&pg=PA10#v=onepage&q&f=false, with a footnote attributing it to "graffiti in the men's room of the Pecan Street Cafe, Austin, Texas". Later publications, such as Paul Davies' 1995 book About Time (p. 236), credited Wheeler with variations of this saying, but the quip is actually much older. The earliest known source is Ray Cummings' 1922 science fiction novel The Girl in the Golden Atom, http://www.gutenberg.org/ebooks/21094 Ch. V: " 'Time,' he said, 'is what keeps everything from happening at once.' " It also appears in his 1929 novel The Man Who Mastered Time. http://books.google.com/books?id=YdZEAAAAYAAJ&q=%22everything+from+happening+at+once%22#search_anchor The earliest known occurrence other than Cummings is from 1962 in Film Facts: Volume 5, p. 48 http://books.google.com/books?id=sr0vAQAAIAAJ&q=%22everything+from+happening+at+once%22. <br class="br">Misattributed
"Albert Einstein" in Biographical Memoirs (1980) Vol. 51, National Academy of Sciences.
"Hermann Weyl and the Unity of Knowledge" http://www.weylmann.com/wheeler.shtml, American Scientist (July-August 1986) Vol. 74, pp. 366-375. Reprinted in At Home in the Universe (1993), p. 171. http://books.google.com/books?id=w9BXAAAAYAAJ&q=%22hermann+weyl+and+the+unity+of+knowledge%22#search_anchor
from a transcript of the video interview "Understanding Relativity," published at webofstories.com