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“Hypotheses non fingo.”

I frame no hypotheses.

A famous statement in the "General Scholium" of the third edition, indicating his belief that the law of universal gravitation was a fundamental empirical law, and that he proposed no hypotheses on how gravity could propagate.

Variant translation: I feign no hypotheses.

As translated by Alexandre Koyré (1956)

I have not as yet been able to discover the reason for these properties of gravity from phenomena, and I do not feign hypotheses. For whatever is not deduced from the phenomena must be called a hypothesis; and hypotheses, whether metaphysical or physical, or based on occult qualities, or mechanical, have no place in experimental philosophy. In this philosophy particular propositions are inferred from the phenomena, and afterwards rendered general by induction.

As translated by I. Bernard Cohen and Anne Whitman (1999)
Philosophiae Naturalis Principia Mathematica (1687)

“Through algebra you easily arrive at equations, but always to pass therefrom to the elegant constructions and demonstrations which usually result by means of the method of porisms is not so easy, nor is one's ingenuity and power of invention so greatly exercised and refined in this analysis.”

The Mathematical Papers of Isaac Newton (edited by Whiteside), Volume 7; Volumes 1691-1695 / pg. 261. http://books.google.com.br/books?id=YDEP1XgmknEC&printsec=frontcover
Geometriae (Treatise on Geometry)

“Daniel was in the greatest credit amongst the Jews, till the reign of the Roman Emperor Hadrian. And to reject his prophecies, is to reject the Christian religion. For this religion is founded upon his prophecy concerning the Messiah.”

Vol. I, Ch. 3: Of the vision of the Image composed of four Metals
Observations upon the Prophecies of Daniel, and the Apocalypse of St. John (1733)

“I have studied these things — you have not.”

Reported as Newton's response, whenever Edmond Halley would say anything disrespectful of religion, by Sir David Brewster in The Life of Sir Isaac Newton (1831). This has often been quoted in recent years as having been a statement specifically defending Astrology. Newton wrote extensively on the importance of Prophecy, and studied Alchemy, but there is little evidence that he took favourable notice of astrology http://www.staff.science.uu.nl/~gent0113/astrology/newton.htm. In a footnote, Brewster attributes the anecdote to the astronomer Nevil Maskelyne who is said to have passed it on to Oxford professor Stephen Peter Rigaud http://books.google.co.uk/books?id=gLcVAAAAYAAJ&pg=PA301&lpg=PA301&dq=brewster+newton+%22I+have+studied%22&source=bl&ots=dEwk6nHcSa&sig=F2uReuXjRWwL3w647pfaU1PlbC0&hl=en&sa=X&ei=fqu5UpzkAvOA7Qap9oGoDQ&ved=0CGoQ6AEwBw#v=onepage&q=brewster%20newton%20%22I%20have%20studied%22&f=false

“The predictions of things to come relate to the state of the Church in all ages: and amongst the old Prophets, Daniel is most distinct in order of time, and easiest to be understood: and therefore in those things which relate to the last times, he must be made the key to the rest.”

Vol. I, Ch. 1: Introduction concerning the Compilers of the books of the Old Testament
Observations upon the Prophecies of Daniel, and the Apocalypse of St. John (1733)
Context: The authority of Emperors, Kings, and Princes, is human. The authority of Councils, Synods, Bishops, and Presbyters, is human. The authority of the Prophets is divine, and comprehends the sum of religion, reckoning Moses and the Apostles among the Prophets; and if an Angel from Heaven preach any other gospel, than what they have delivered, let him be accursed. Their writings contain covenant between God and his people, with instructions for keeping this covenant; instances of God’s judgments upon them that break it: and predictions of things to come. While the people of God keep the covenant they continue to be his people: when they break it they cease to be his people or church, and become the Synagogue of Satan, who say they are Jews and are not. And no power on earth is authorized to alter this covenant.
The predictions of things to come relate to the state of the Church in all ages: and amongst the old Prophets, Daniel is most distinct in order of time, and easiest to be understood: and therefore in those things which relate to the last times, he must be made the key to the rest.

“In the beginning of the year 1665 I found the method of approximating Series and the Rule for reducing any dignity of any Binomial into such a series. The same year in May I found the method of tangents of Gregory and Slusius, and in November had the direct method of Fluxions, and the next year in January had the Theory of Colours, and in May following I had entrance into the inverse method of Fluxions. And the same year I began to think of gravity extending to the orb of the Moon, and having found out how to estimate the force with which [a] globe revolving within a sphere presses the surface of the sphere, from Kepler's Rule of the periodical times of the Planets being in a sesquialterate proportion of their distances from the centers of their orbs I deduced that the forces which keep the Planets in their Orbs must [be] reciprocally as the squares of their distances from the centers about which they revolve: and thereby compared the force requisite to keep the Moon in her orb with the force of gravity at the surface of the earth, and found them answer pretty nearly. All this was in the two plague years of 1665 and 1666, for in those days I was in the prime of my age for invention, and minded Mathematicks and Philosophy more than at any time since. What Mr Hugens has published since about centrifugal forces I suppose he had before me. At length in the winter between the years 1676 and 1677 I found the Proposition that by a centrifugal force reciprocally as the square of the distance a Planet must revolve in an Ellipsis about the center of the force placed in the lower umbilicus of the Ellipsis and with a radius drawn to that center describe areas proportional to the times. And in the winter between the years 1683 and 1684 this Proposition with the Demonstration was entered in the Register book of the R. Society. And this is the first instance upon record of any Proposition in the higher Geometry found out by the method in dispute. In the year 1689 Mr Leibnitz, endeavouring to rival me, published a Demonstration of the same Proposition upon another supposition, but his Demonstration proved erroneous for want of skill in the method.”

(ca. 1716) A Catalogue of the Portsmouth Collection of Books and Papers Written by Or Belonging to Sir Isaac Newton https://books.google.com/books?id=3wcjAAAAMAAJ&pg=PR18 (1888) Preface
Also partially quoted in Sir Sidney Lee (ed.), The Dictionary of National Biography Vol.40 http://books.google.com/books?id=NycJAAAAIAAJ (1894)

“God created everything by number, weight and measure.”
Numero pondere et mensura Deus omnia condidit.

As quoted in Symmetry in Plants (1998) by Roger V. Jean and Denis Barabé, p. xxxvii, a translation of a Latin phrase he wrote in a student's notebook, elsewhere given as Numero pondere et mensura Deus omnia condidit. This is similar to Latin statements by Thomas Aquinas, and even more ancient statements of the Greek philosopher Pythagoras. See also Wisdom of Solomon 11:20 https://en.wikisource.org/wiki/Bible_(King_James)/Wisdom_of_Solomon#Chapter_11