“There is no discredit, though there is at times much discomfort, in this everlasting perhaps with which we have to preface so much connected with the practice of our art. It is, as I said, inherent in the subject.”
On the Educational Value of the Medical Society (1903)
Context: Surrounded by people who demand certainty, — and not philosopher enough to agree with Locke that "Probability supplies the defect of our knowledge and guides us when that fails, and is always conversant about things of which we have no certainty," the practitioner too often gets into a habit of mind which resents the thought that opinion, not full knowledge, must be his stay and prop. There is no discredit, though there is at times much discomfort, in this everlasting perhaps with which we have to preface so much connected with the practice of our art. It is, as I said, inherent in the subject.
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William Osler 50
Canadian pathologist, physician, educator, bibliophile, his… 1849–1919Related quotes

Source: On writing about a topic even if it is recent in “Kamila Shamsie: ‘Being a UK citizen makes me feel more able to take part in the conversation’” https://www.theguardian.com/books/2017/aug/27/kamila-shamsie-home-fire-man-booker-longlisted-author-interview in The Guardian (2017 Aug 27)

Engagement interview (November 2017)

“The reason it hurts so much to separate is because our souls are connected.”

Essay as "Mr. X" (1969)
Context: The cannabis experience has greatly improved my appreciation for art, a subject which I had never much appreciated before. The understanding of the intent of the artist which I can achieve when high sometimes carries over to when I'm down. This is one of many human frontiers which cannabis has helped me traverse. There also have been some art-related insights — I don't know whether they are true or false, but they were fun to formulate.

Quote from Constable's letter to Rev. John Fisher (22 July 1812), as quoted in Richard Friedenthal, Letters of the great artists – from Blake to Pollock (Thames and Hudson, London, 1963), p. 40
1800s - 1810s

for that, much is lacking. The ideal of morality belongs to culture; its use for some simulacrum of morality in the love of honor and outward decorum constitutes mere civilization. So long as states waste their forces in vain and violent self-expansion, and thereby constantly thwart the slow efforts to improve the minds of their citizens by even withdrawing all support from them, nothing in the way of a moral order is to be expected. For such an end, a long internal working of each political body toward the education of its citizens is required. Everything good that is not based on a morally good disposition, however, is nothing but pretense and glittering misery. In such a condition the human species will no doubt remain until, in the way I have described, it works its way out of the chaotic conditions of its international relations.
Seventh Thesis
Idea for a Universal History from a Cosmopolitan Point of View (1784)

An Essay on the Art of Decyphering (1737)
Context: Partly out of my owne Curiosity, partly to satisfy the Gentleman's Importunity that did request it, I resolved to try what I could do in it: And having projected the best Methods I could think of for the effecting it, I found yet so hard a Task, that I did divers Times give it over as desperate: Yet, after some Intermissions, resuming it againe, I did at last overcome the Difficulty; but with so much Paines and Expense of Time as I am not willing to mention; though yet I did not repent of that Labour, when I had discovered thereby, that it was a Businesse, which though with much Difficulty, was yet capable to bee effected.<!--p.13

Source: Ulysses (1842), l. 63-70
Context: It may be that the gulfs will wash us down;
It may be that we shall touch the Happy Isles,
And see the great Achilles, whom we knew.
Though much is taken, much abides; and though
We are not now that strength which in old days
Moved earth and heaven, that which we are, we are —
One equal temper of heroic hearts,
Made weak by time and fate, but strong in will
To strive, to seek, to find, and not to yield.