“A week ago today I received a great honor, and all the great responsibilities that come with it.”

The Transhumanism Handbook, 2019

Amazing Fantasy #15 (August 1962) – The first Spider-Man story.
In later stories and adaptations, including the 2002 movie, this has appeared as "With great power comes great responsibility."
The saying pre-dates Amazing Fantasy. The phrase "with great power goes great responsibility" was spoken by J. Hector Fezandie in an 1894 graduation address at The Stevens Institute of Technology - "The Moral Influence of a Scientific Education", The Stevens Indicator, Volume 11, Page 217. The exact phrase was repeated during a speech by President Harry S. Truman in November 1950 - Public Papers of the Presidents of the United States: Harry S. Truman, 6666 (published 1965), Page 703. A UK Member of Parliament implied in 1817 that a variant of it was already a cliché ([1817, 1227, Parliamentary Debates, Thomas C. Hansard, http://books.google.co.uk/books?lr=&output=text&as_brr=0&as_drrb_is=b&as_minm_is=0&as_miny_is=&as_maxm_is=0&as_maxy_is=1850&id=B6w9AAAAcAAJ&dq=%22great-power+*+great-responsibility%22&q=%22%22that%2Bthe%2Bpossession%2Bof%2Bgreat%2Bpower%2Bnecessarily%2Bimplies%2Bgreat%2Bresponsibility%22%26hl%3Den%26sa%3DX%26ei%3DYX5WUqnYGaiO4wT9poCwBQ%26ved%3D0CDMQ6wEwAA%23v%3Donepage%26q%3D%22that+the+possession+of+great+power+necessarily+implies+great+responsibility%22%26f%3Dfalse%22#v=onepage&q=%22%22that%2Bthe%2Bpossession%2Bof%2Bgreat%2Bpower%2Bnecessarily%2Bimplies%22&f=false, October 10, 2013, He should, however, beg leave to remind the conductors of the press of their duty to apply to themselves a maxim which they never neglected to urge on the consideration of government—" that the possession of great power necessarily implies great responsibility."] The editor is quoting William Lamb (pp. 1125–1229)). The sentiment is also found in Luke 12:48: "from the one who has been entrusted with much, much more will be asked" (NIV).

No. 497 (30 September 1712)
The Spectator (1711-1714)

On how much his wife "Angel" meant to him, just before receiving the Presidential Medal of Freedom at the White House (9 November 2005), as quoted in "Paul Harvey's Wife Dies at Age 92" in ABC News (4 May 2008) http://abcnews.go.com/print?id=4780941.

2013, Brandenburg Gate Speech (June 2013)

2009, Nobel Prize acceptance speech (December 2009)
Context: I receive this honor with deep gratitude and great humility. It is an award that speaks to our highest aspirations — that for all the cruelty and hardship of our world, we are not mere prisoners of fate. Our actions matter, and can bend history in the direction of justice.
And yet I would be remiss if I did not acknowledge the considerable controversy that your generous decision has generated. In part, this is because I am at the beginning, and not the end, of my labors on the world stage. Compared to some of the giants of history who've received this prize — Schweitzer and King; Marshall and Mandela — my accomplishments are slight. And then there are the men and women around the world who have been jailed and beaten in the pursuit of justice; those who toil in humanitarian organizations to relieve suffering; the unrecognized millions whose quiet acts of courage and compassion inspire even the most hardened cynics. I cannot argue with those who find these men and women — some known, some obscure to all but those they help — to be far more deserving of this honor than I.
But perhaps the most profound issue surrounding my receipt of this prize is the fact that I am the Commander-in-Chief of the military of a nation in the midst of two wars. One of these wars is winding down. The other is a conflict that America did not seek; one in which we are joined by 42 other countries — including Norway — in an effort to defend ourselves and all nations from further attacks.
Still, we are at war, and I'm responsible for the deployment of thousands of young Americans to battle in a distant land. Some will kill, and some will be killed. And so I come here with an acute sense of the costs of armed conflict — filled with difficult questions about the relationship between war and peace, and our effort to replace one with the other.

"Debió de recibir una buena noticia, porque ayer tenía el pelo blanco y hoy apareció completamente rubia."
Descanso de caminantes, 2001.

1961, The City upon a Hill speech
Context: During the last sixty days, I have been at the task of constructing an administration. It has been a long and deliberate process. Some have counseled greater speed. Others have counseled more expedient tests. But I have been guided by the standard John Winthrop set before his shipmates on the flagship Arbella three hundred and thirty-one years ago, as they, too, faced the task of building a new government on a perilous frontier. "We must always consider," he said, "that we shall be as a city upon a hill — the eyes of all people are upon us." Today the eyes of all people are truly upon us — and our governments, in every branch, at every level, national, state and local, must be as a city upon a hill — constructed and inhabited by men aware of their great trust and their great responsibilities. For we are setting out upon a voyage in 1961 no less hazardous than that undertaken by the Arbella in 1630. We are committing ourselves to tasks of statecraft no less awesome than that of governing the Massachusetts Bay Colony, beset as it was then by terror without and disorder within. History will not judge our endeavors — and a government cannot be selected — merely on the basis of color or creed or even party affiliation. Neither will competence and loyalty and stature, while essential to the utmost, suffice in times such as these.