“God doesn't give a damn.”

The Pusher (1968)

Source: Handle with Care

VALIS (1981)

Flowers for Algernon (1966)
Context: Intelligence alone doesn't mean a damned thing. Here in your university, intelligence, education, knowledge, have all become great idols. But I know now there's one thing you've all overlooked: intelligence and education that hasn't been tempered by human affection isn't worth a damn.

Source: Straight From The Heart (1985), Chapter Five, A Balancing Act, p. 111-112

Source: Night Embrace

Environmentalism as a Religion (2003)
Context: The notion that the natural world obeys its own rules and doesn't give a damn about your expectations comes as a massive shock... it will demand that you adapt to it — and if you don't, you die. It is a harsh, powerful, and unforgiving world, that most urban westerners have never experienced.

Comments to James H. Wilson (22 October 1864), as quoted in Under the Old Flag: Recollections of Military Operations in the War for the Union, the Spanish War, the Boxer Rebellion, etc Vol. 2 (1912) by James Harrison Wilson, p. 17.
1860s, 1864
Context: I am a damned sight smarter man than Grant. I know more about military history, strategy, and grand tactics than he does. I know more about supply, administration, and everything else than he does. I'll tell you where he beats me though and where he beats the world. He doesn't give a damn about what the enemy does out of his sight, but it scares me like hell. … I am more nervous than he is. I am more likely to change my orders or to countermarch my command than he is. He uses such information as he has according to his best judgment; he issues his orders and does his level best to carry them out without much reference to what is going on about him and, so far, experience seems to have fully justified him.

Source: Gone with the Wind