“Mistake me not, my brethren: I am not speaking against learning in itself; it is a precious gift of God, and may be happily improved in the service of the gospel; but I will venture to say, in the spirit of the apostle Paul's writings in general, and of this passage in particular, Accursed be all that learning which sets itself in opposition to the cross of Christ! Accursed be all that learning which disguises or is ashamed of the cross of Christ! Accursed be all that learning which fills the room that is due to the cross of Christ! and once more, Accursed be all that learning which is not made subservient to the honour and glory of the cross of Christ!”

—  John Witherspoon

From the sermon "Glorying in the Cross", published in 1768. Misquoted since 1845 as "Cursed be all that learning that is contrary to the cross of Christ; cursed be all that learning that is not coincident with the cross of Christ; cursed be all that learning that is not subservient to the cross of Christ." So quoted by S. S. Cox in October 1845, in Permanent Documents of the Society for the Promotion of Collegiate and Theological Education at the West, Volume 1, p. 30.

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John Witherspoon 3
Scottish-American Presbyterian minister and a Founding Fath… 1723–1794

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A paraphrase of a statement by John Witherspoon, who was president of Princeton when Madison attended the school, in a sermon "Glorying in the Cross"(1768):
:: Accursed be all that learning which sets itself in opposition to the cross of Christ!
::* This has appeared in the paraphrased form since at least 1845; how it came to be attributed to Madison is unknown.
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6:10 - 20 (KJV) https://www.biblegateway.com/passage/?search=Ephesians+6&version=KJV;SBLGNT
Variant translation:
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Epistle to the Ephesians
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¶ 157 - 158.
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