“I don't believe in rock bottom. Rock bottom is like a fishing term.”

American on Purpose (2009)

"What Life Has Taught Me"
Autobiography of Swami Sivananda
Context: I consider that goodness of being and doing constitute the rock-bottom of one’s life. By goodness I mean the capacity to feel with others and to live and feel as others do, and be in a position to act so that no one is hurt by the act. Goodness is the face of Godliness. I think that to be good in reality, in the innermost recesses of one’s heart, is not easy, though it may appear to be simple as a teaching. It is one of the hardest things on earth, if only one would be honest with oneself.
There is no physical world for me. What I see I see as the glorious manifestation of the Almighty.

Harvard address (2008)

On being hospitalized for depression in “Terese Mailhot: Truth Is My Aesthetic” https://www.guernicamag.com/terese-mailhot-truth-is-my-aesthetic/ in Guernica Magazine (2018 Mar 21)

Variant: Just when you think you’ve hit rock bottom, someone will hand you a shovel.
Source: Head Over Heels

Source: Night Film

As translated by Ejvind Haas
Siddhartha (1922)
Context: When you throw a rock into the water, it will speed on the fastest course to the bottom of the water. This is how it is when Siddhartha has a goal, a resolution. Siddhartha does nothing, he waits, he thinks, he fasts, but he passes through the things of the world like a rock through water, without doing anything, without stirring; he is drawn, he lets himself fall. His goal attracts him, because he doesn't let anything enter his soul which might oppose the goal. This is what Siddhartha has learned among the Samanas. This is what fools call magic and of which they think it would be effected by means of the daemons. Nothing is effected by daemons, there are no daemons. Everyone can perform magic, everyone can reach his goals, if he is able to think, if he is able to wait, if he is able to fast.

The Atheism Tapes (2004)
Context: Maybe at the very bottom of it... I really don't like God. You know, it's silly to say I don't like God because I don't believe in God, but in the same sense that I don't like Iago, or the Reverend Slope or any of the other villains of literature, the god of traditional Judaism and Christianity and Islam seems to me a terrible character. He's a god who will... who obsessed the degree to which people worship him and anxious to punish with the most awful torments those who don't worship him in the right way. Now I realise that many people don't believe in that any more who call themselves Muslims or Jews or Christians, but that is the traditional God and he's a terrible character. I don't like him.

Part of a statement at the annual meeting of the Massachusetts Medical Society (30 May 1860), generally quoted in a simplified form omitting Holmes's exceptions including opium and anaesthetics.
Throw out opium, which the Creator himself seems to prescribe, for we often see the scarlet poppy growing in the cornfields, as if it were foreseen that wherever there is hunger to be fed there must also be a pain to be soothed; throw out a few specifics which our art did not discover, and it is hardly needed to apply; throw out wine, which is a food, and the vapors which produce the miracle of anaesthesia, and I firmly believe that if the whole materia medica [medical drugs], as now used, could be sunk to the bottom of the sea, it would be all the better for mankind,—and all the worse for the fishes.
As quoted in a review of Currents and Counter-currents in Medical Science (1860) in The American Journal of the Medical Sciences, Vol. 40 (1860), p. 467 http://books.google.co.uk/books?id=zHdDAAAAYAAJ&pg=PA467
Paraphrased variant: If all the medicine in the world were thrown into the sea, it would be bad for the fish and good for humanity.