“Among the many early revelations from molecular phylogenetic studies of bacteria (Woese, 1987) was the recognition that the mycoplasmas represented an evolutionarily derived condition rather than a primitive one, as once believed. Now that phylogenetic relationships and genome sizes are determined for a broader array of organisms, it is clear that the mycoplasmas are just one example of genome shrinkage that has occurred in a variety of obligately host-associated bacteria. Other prominent examples are Rickettsia and related pathogens within the α-proteobacteria; insect symbionts within the γ-proteobacteria, as exemplified by Buchnera aphidicola in aphids; the chlamydiae; and the parasitic spirochetes, such as Borrelia burgdorferi”

the agent of Lyme disease
[Cell, 108, 5, 8 March 2002, 583–586, Minireview Microbial Minimalism: Genome Reduction in Bacterial Pathogens, 10.1016/S0092-8674(02)00665-7]

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Nancy A. Moran 9
American biologist 1954

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