“But in practical science, the question is—What are we to do?—a question which involves the necessity for the immediate adoption of some rule of working. In doubtful cases, we cannot allow our machines and our works of improvement to wait for the advancement of science; and if existing data are insufficient to give an exact solution of the question, that approximate solution must be acted upon which the best data attainable show to be the most probable. A prompt and sound judgment in cases of this kind is one of the characteristics of a Practical Man in the right sense of that term.”

p, 125
"On the Harmony of Theory and Practice in Mechanics" (Jan. 3, 1856)

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William John Macquorn Rankine28

civil engineer 1820–1872

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“In theoretical science, the question is—What are we to think? and when a doubtful point arises, for the solution of which either experimental data are wanting, or mathematical methods are not sufficiently advanced, it is the duty of philosophic minds not to dispute about the probability of conflicting suppositions, but to labour for the advancement of experimental inquiry and of mathematics, and await patiently the time when they shall be adequate to solve the question.”

William John Macquorn Rankine (1820–1872) civil engineer

p, 125
"On the Harmony of Theory and Practice in Mechanics" (Jan. 3, 1856)

“Life is made up of a series of judgments on insufficient data, and if we waited to run down all our doubts, it would flow past us.”

Learned Hand (1872–1961) American legal scholar, Court of Appeals judge

"On Receiving an Honorary Degree" (1939).
Extra-judicial writings

“Science is meaningless because it gives no answer to our question, the only question important for us: 'what shall we do and how shall we live”

Leo Tolstoy (1828–1910) Russian writer

Quoted by Max Weber in his lecture "Science as a Vocation"; in Lynda Walsh (2013), Scientists as Prophets: A Rhetorical Genealogy (2013), Oxford University Press, p. 90

“To me this question whether liberty is a good or a bad thing appears as irrational as the question whether fire is a good or a bad thing. It is both good and bad according to time, place, and circumstance, and a complete answer to the question, In what cases is liberty good and in what cases is it bad? would involve not merely a universal history of mankind, but a complete solution of the problems which such a history would offer.”

James Fitzjames Stephen (1829–1894) Indian judge

Source: Liberty, Equality, Fraternity (1873-1874), Ch. 2

“There was no solution, save that universal solution which life gives to all questions, even the most complex and insolvable: One must live in the needs of the day--that is, forget oneself.”

Leo Tolstoy book Anna Karenina

Source: Anna Karenina

“The fundamental thesis of ordinary conventionalism, represented for instance by Poincare, states that there are problems which cannot be solved by appeal to experience unless one introduces a certain convention, since only such a convention, together with experimental data, makes it possible to solve the problem in question. The judgements which combine to make up such a solution are thus not forced on us by empirical data alone, but their adoption depends partly on our recognition, since the said convention which co-determines the solution of the problem can be arbitrarily changed by us so that as a result we obtain different judgements.
In the present paper it is my intention to make that thesis of ordinary conventionalism more general and more radical. Namely, we want to formulate and to prove the theorem that not only some, but all the judgements which we accept and which combine to make up our image of the world are not univocally determined by empirical data, but depend on the choice of the conceptual apparatus by means of which we make mappings of those empirical data. We can, however, choose this or that conceptual apparatus, which will change our whole image of the world.”

Kazimierz Ajdukiewicz (1890–1963) Philosopher, logician

Kazimierz Ajdukiewicz, "Das Weltbild und die Begriffsapparatur", in Erkenntnis, 1934, Vol. 4, p. 259; as cited in: Schaff (1962;81-82)

“The research questions that motivate most quantitative studies in the health, social and behavioral sciences are not statistical but causal in nature. For example, what is the efficacy of a given drug in a given population? Whether data can prove an employer guilty of hiring discrimination? What fraction of past crimes could have been avoided by a given policy? What was the cause of death of a given individual, in a specific incident? These are causal questions because they require some knowledge of the data-generating process; they cannot be computed from the data alone.”

Judea Pearl (1936) Computer scientist

Pearl, Judea (2008) "Causal Inference," in: Pearl, Judea. The science and ethics of causal modeling. (2010).

“These sublime and profound themes admit of no proof whatever… In all questions that cannot be demonstrated, we must adopt the method which we have adopted in this question about God's Omniscience. Note it.”

Maimónides book The Guide for the Perplexed

Source: Guide for the Perplexed (c. 1190), Part III, Ch.21
Context: He fully knows His unchangeable essence, and has thus a knowledge of all that results from any of His acts. If we were to try to understand in what manner this is done, it would be the same as if we tried to be the same as God, and to make our knowledge identical with His knowledge. Those who seek the truth, and admit what is true, must believe that nothing is hidden from God; that everything is revealed to His knowledge, which is identical with His essence; that this kind of knowledge cannot be comprehended by us; for if we knew its method, we would possess that intellect by which such knowledge could be acquired.... Note this well, for I think that this is an excellent idea, and leads to correct views; no error will be found in it; no dialectical argument; it does not lead to any absurd conclusion, nor to ascribing any defect to God. These sublime and profound themes admit of no proof whatever... In all questions that cannot be demonstrated, we must adopt the method which we have adopted in this question about God's Omniscience. Note it.

“You are no doubt aware that the Almighty, desiring to lead us to perfection and to improve our state of society, has revealed to us laws which are to regulate our actions. These laws, however, presuppose an advanced state of intellectual culture. We must first form a conception of the Existence of the Creator according to our capabilities; that is, we must have a knowledge of Metaphysics. But this discipline can only be approached after the study of Physics: for the science of Physics borders on Metaphysics, and must even precede it in the course of our studies, as is clear to all who are familiar with these questions.”

Maimónides book The Guide for the Perplexed

Guide for the Perplexed (c. 1190), Introduction

“While it is true that science cannot decide questions of value, that is because they cannot be intellectually decided at all, and lie outside the realm of truth and falsehood. Whatever knowledge is attainable, must be attained by scientific methods; and what science cannot discover, mankind cannot know.”

Bertrand Russell book Religion and Science

Religion and Science (1935), Ch. IX: Science of Ethics.
1930s
Variant: "What science cannot tell us, mankind cannot know." (Attributed to Russell in Ted Peters' Cosmos As Creation: Theology and Science in Consonance [1989], p. 14, with a note that it was "told [to] a BBC audience [earlier this century]").

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William John Macquorn Rankine28

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