“the confluent smallpox - invented perhaps as the cruellest remedy for human vanity”

"The Panda's Thumb of Technology", p. 65
Bully for Brontosaurus (1991)

Cassandra (1860)
Context: By mortifying vanity we do ourselves no good. It is the want of interest in our life which produces it; by filling up that want of interest in our life we can alone remedy it. And, did we even see this, how can we make the difference? How obtain the interest which society declares she does not want, and we cannot want?

New Yorker magazine, April 23 2003

Who Speaks for Man? (1953), p. 318.

On Literature, Revolution, Entropy and Other Matters (1923)
Context: The law of revolution is red, fiery, deadly; but this death means the birth of new life, a new star. And the law of entropy is cold, ice blue, like the icy interplanetary infinities. The flame turns from red to an even, warm pink, no longer deadly, but comfortable. The sun ages into a planet, convenient for highways, stores, beds, prostitutes, prisons: this is the law. And if the planet is to be kindled into youth again, it must be set on fire, it must be thrown off the smooth highway of evolution: this is the law.
The flame will cool tomorrow, or the day after tomorrow (in the Book of Genesis days are equal to years, ages). But someone must see this already today, and speak heretically today about tomorrow. Heretics are the only (bitter) remedy against the entropy of human thought.

"Keep Your Filthy Hands Off The Internet" 20 June 2010.

Presidency (1977–1981), Farewell Address (1981)
Context: America did not invent human rights. In a very real sense, it is the other way round. Human rights invented America.
Ours was the first nation in the history of the world to be founded explicitly on such an idea.
Context: I have just been talking about forces of potential destruction that mankind has developed, and how we might control them. It is equally important that we remember the beneficial forces that we have evolved over the ages, and how to hold fast to them.
One of those constructive forces is enhancement of individual human freedoms through the strengthening of democracy, and the fight against deprivation, torture, terrorism and the persecution of people throughout the world. The struggle for human rights overrides all differences of color, nation or language.
Those who hunger for freedom, who thirst for human dignity, and who suffer for the sake of justice — they are the patriots of this cause.
I believe with all my heart that America must always stand for these basic human rights — at home and abroad. That is both our history and our destiny.
America did not invent human rights. In a very real sense, it is the other way round. Human rights invented America.
Ours was the first nation in the history of the world to be founded explicitly on such an idea. Our social and political progress has been based on one fundamental principle — the value and importance of the individual. The fundamental force that unites us is not kinship or place of origin or religious preference. The love of liberty is a common blood that flows in our American veins.

Variant: Let us think often that our only business in this life is to please God. Perhaps all besides is but folly and vanity.
Source: The Practice of the Presence of God

Fiction, The Enemy in the Blanket (1958)